Effect of P2Y(1) and P2Y(12) genetic polymorphisms on the ADP-induced platelet aggregation in a Korean population
DC Field | Value | Language |
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dc.contributor.author | Kim, Kyoung-Ah | - |
dc.contributor.author | Song, Wan-Geun | - |
dc.contributor.author | Lee, Hye-Mi | - |
dc.contributor.author | Joo, Hyun-Jin | - |
dc.contributor.author | Park, Ji-Young | - |
dc.date.accessioned | 2021-09-05T23:24:50Z | - |
dc.date.available | 2021-09-05T23:24:50Z | - |
dc.date.created | 2021-06-14 | - |
dc.date.issued | 2013-08 | - |
dc.identifier.issn | 0049-3848 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/102629 | - |
dc.description.abstract | Background: P2Y(1) and P2Y(12) receptors are expressed in platelet membranes and are involved in ADP-induced platelet aggregation. Genetic polymorphisms of P2Y(1) and P2Y(12) play a major role in the variation of ADP-induced platelet aggregation and in response in antiplatelet therapy. Objective: To evaluate the allele frequencies of P2Y(1) and P2Y(12) genetic polymorphisms in a Korean population and to assess their role in ADP (5 mu mol/L)-induced maximal platelet aggregation. Methods: P2Y(1) (c.1622A > G) and P2Y(12) (i-139C > T, i-744 T > C, i-ins801, c.52G > T, c.34C > T) polymorphisms were analyzed in 158 Korean healthy participants using pyrosequencing methods. Their ADP-induced maximal platelet aggregation was assessed by the turbidometric method. Results: The observed allele frequencies of P2Y(1) and P2Y(12) were as follows: 0.3101 for P2Y(1) c.1622A > G; 0.1804 for P2Y(12) i-139C > T, 0.1804 for i-744 T > C, 0.1804 for i-801insA, 0.1266 for P2Y(12) c.52G > T, and 0.2658 for P2Y(12) c.34C > T. ADP-induced maximal platelet aggregation was not influenced by the P2Y(1) c.1622A > G polymorphism and was also not affected by three intronic P2Y(12) polymorphisms and the P2Y(12) c.34C > T polymorphism. However, the P2Y(12) c.52G > T polymorphism caused a substantial difference in ADP-induced maximal platelet aggregation (62.75% for c.52GG, 66.27% for c.52GT, and 80.60% for c.52TT; P = 0.0092). Conclusions: The P2Y(1) and P2Y(12) genes were very polymorphic in a Korean population. Three intronic P2Y(12) polymorphisms (i-139C > T, i-744 T > C, i-801insA) were in complete linkage disequilibrium but not with the c.52C > T polymorphism in this population. Maximal platelet aggregation in response to ADP is associated with the c.52C > T polymorphism but not with the three intronic polymorphisms or the P2Y(1) c.1622A > T polymorphism. (c) 2013 Elsevier Ltd. All rights reserved. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | PERGAMON-ELSEVIER SCIENCE LTD | - |
dc.subject | HEALTHY-SUBJECTS | - |
dc.subject | SEQUENCE VARIATIONS | - |
dc.subject | ARTERY-DISEASE | - |
dc.subject | RECEPTOR GENE | - |
dc.subject | P2Y12 GENE | - |
dc.subject | CLOPIDOGREL | - |
dc.subject | ASSOCIATION | - |
dc.subject | PHARMACOKINETICS | - |
dc.subject | HAPLOTYPE | - |
dc.subject | ASPIRIN | - |
dc.title | Effect of P2Y(1) and P2Y(12) genetic polymorphisms on the ADP-induced platelet aggregation in a Korean population | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Park, Ji-Young | - |
dc.identifier.doi | 10.1016/j.thromres.2013.06.020 | - |
dc.identifier.scopusid | 2-s2.0-84883817160 | - |
dc.identifier.wosid | 000324059600029 | - |
dc.identifier.bibliographicCitation | THROMBOSIS RESEARCH, v.132, no.2, pp.221 - 226 | - |
dc.relation.isPartOf | THROMBOSIS RESEARCH | - |
dc.citation.title | THROMBOSIS RESEARCH | - |
dc.citation.volume | 132 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 221 | - |
dc.citation.endPage | 226 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Hematology | - |
dc.relation.journalResearchArea | Cardiovascular System & Cardiology | - |
dc.relation.journalWebOfScienceCategory | Hematology | - |
dc.relation.journalWebOfScienceCategory | Peripheral Vascular Disease | - |
dc.subject.keywordPlus | HEALTHY-SUBJECTS | - |
dc.subject.keywordPlus | SEQUENCE VARIATIONS | - |
dc.subject.keywordPlus | ARTERY-DISEASE | - |
dc.subject.keywordPlus | RECEPTOR GENE | - |
dc.subject.keywordPlus | P2Y12 GENE | - |
dc.subject.keywordPlus | CLOPIDOGREL | - |
dc.subject.keywordPlus | ASSOCIATION | - |
dc.subject.keywordPlus | PHARMACOKINETICS | - |
dc.subject.keywordPlus | HAPLOTYPE | - |
dc.subject.keywordPlus | ASPIRIN | - |
dc.subject.keywordAuthor | P2Y(1) | - |
dc.subject.keywordAuthor | P2Y(12) | - |
dc.subject.keywordAuthor | Polymorphism | - |
dc.subject.keywordAuthor | ADP | - |
dc.subject.keywordAuthor | Platelet aggregation | - |
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