MG53-induced IRS-1 ubiquitination negatively regulates skeletal myogenesis and insulin signalling
DC Field | Value | Language |
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dc.contributor.author | Yi, Jae-Sung | - |
dc.contributor.author | Park, Jun Sub | - |
dc.contributor.author | Ham, Young-Mi | - |
dc.contributor.author | Nguyen, Nga | - |
dc.contributor.author | Lee, Na-Rae | - |
dc.contributor.author | Hong, Jin | - |
dc.contributor.author | Kim, Bong-Woo | - |
dc.contributor.author | Lee, Hyun | - |
dc.contributor.author | Lee, Chang-Seok | - |
dc.contributor.author | Jeong, Byung-Cheon | - |
dc.contributor.author | Song, Hyun Kyu | - |
dc.contributor.author | Cho, Hana | - |
dc.contributor.author | Kim, Yoon Ki | - |
dc.contributor.author | Lee, Jae-Seon | - |
dc.contributor.author | Park, Kyong Soo | - |
dc.contributor.author | Shin, Haksub | - |
dc.contributor.author | Choi, Inho | - |
dc.contributor.author | Lee, Seung Hee | - |
dc.contributor.author | Park, Woo Jin | - |
dc.contributor.author | Park, Shi-Young | - |
dc.contributor.author | Choi, Cheol Soo | - |
dc.contributor.author | Lin, Peihui | - |
dc.contributor.author | Karunasiri, Malith | - |
dc.contributor.author | Tan, Tao | - |
dc.contributor.author | Duann, Pu | - |
dc.contributor.author | Zhu, Hua | - |
dc.contributor.author | Ma, Jianjie | - |
dc.contributor.author | Ko, Young-Gyu | - |
dc.date.accessioned | 2021-09-05T23:25:16Z | - |
dc.date.available | 2021-09-05T23:25:16Z | - |
dc.date.created | 2021-06-14 | - |
dc.date.issued | 2013-08 | - |
dc.identifier.issn | 2041-1723 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/102632 | - |
dc.description.abstract | Mitsugumin 53 (MG53) negatively regulates skeletal myogenesis by targeting insulin receptor substrate 1 (IRS-1). Here, we show that MG53 is an ubiquitin E3 ligase that induces IRS-1 ubiquitination with the help of an E2-conjugating enzyme, UBE2H. Molecular manipulations that disrupt the E3-ligase function of MG53 abolish IRS-1 ubiquitination and enhance skeletal myogenesis. Skeletal muscles derived from the MG53(-/-) mice show an elevated IRS-1 level with enhanced insulin signalling, which protects the MG53(-/-) mice from developing insulin resistance when challenged with a high-fat/high-sucrose diet. Muscle samples derived from human diabetic patients and mice with insulin resistance show normal expression of MG53, indicating that altered MG53 expression does not serve as a causative factor for the development of metabolic disorders. Thus, therapeutic interventions that target the interaction between MG53 and IRS-1 may be a novel approach for the treatment of metabolic diseases that are associated with insulin resistance. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | NATURE PUBLISHING GROUP | - |
dc.subject | GROWTH-FACTOR-I | - |
dc.subject | MUSCLE ATROPHY | - |
dc.subject | TARGETED DISRUPTION | - |
dc.subject | ECTOPIC EXPRESSION | - |
dc.subject | IGF-I | - |
dc.subject | RECEPTOR | - |
dc.subject | HYPERTROPHY | - |
dc.subject | PATHWAY | - |
dc.subject | DIFFERENTIATION | - |
dc.subject | INFLAMMATION | - |
dc.title | MG53-induced IRS-1 ubiquitination negatively regulates skeletal myogenesis and insulin signalling | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Song, Hyun Kyu | - |
dc.contributor.affiliatedAuthor | Kim, Yoon Ki | - |
dc.contributor.affiliatedAuthor | Ko, Young-Gyu | - |
dc.identifier.doi | 10.1038/ncomms3354 | - |
dc.identifier.scopusid | 2-s2.0-84883166199 | - |
dc.identifier.wosid | 000323753200015 | - |
dc.identifier.bibliographicCitation | NATURE COMMUNICATIONS, v.4 | - |
dc.relation.isPartOf | NATURE COMMUNICATIONS | - |
dc.citation.title | NATURE COMMUNICATIONS | - |
dc.citation.volume | 4 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Science & Technology - Other Topics | - |
dc.relation.journalWebOfScienceCategory | Multidisciplinary Sciences | - |
dc.subject.keywordPlus | GROWTH-FACTOR-I | - |
dc.subject.keywordPlus | MUSCLE ATROPHY | - |
dc.subject.keywordPlus | TARGETED DISRUPTION | - |
dc.subject.keywordPlus | ECTOPIC EXPRESSION | - |
dc.subject.keywordPlus | IGF-I | - |
dc.subject.keywordPlus | RECEPTOR | - |
dc.subject.keywordPlus | HYPERTROPHY | - |
dc.subject.keywordPlus | PATHWAY | - |
dc.subject.keywordPlus | DIFFERENTIATION | - |
dc.subject.keywordPlus | INFLAMMATION | - |
dc.subject.keywordAuthor | MG53 | - |
dc.subject.keywordAuthor | IRS-1 | - |
dc.subject.keywordAuthor | ubiquitination | - |
dc.subject.keywordAuthor | insulin signalling | - |
dc.subject.keywordAuthor | insulin resistance | - |
dc.subject.keywordAuthor | myogenesis | - |
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