Association between tumor necrosis factor-alpha promoter -308 A/G,-238 A/G, interleukin-6 -174 G/C and -572 G/C polymorphisms and periodontal disease: a meta-analysis
DC Field | Value | Language |
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dc.contributor.author | Song, Gwan Gyu | - |
dc.contributor.author | Choi, Sung Jae | - |
dc.contributor.author | Ji, Jong Dae | - |
dc.contributor.author | Lee, Young Ho | - |
dc.date.accessioned | 2021-09-05T23:29:17Z | - |
dc.date.available | 2021-09-05T23:29:17Z | - |
dc.date.created | 2021-06-14 | - |
dc.date.issued | 2013-08 | - |
dc.identifier.issn | 0301-4851 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/102656 | - |
dc.description.abstract | The aim of this study was to determine whether tumor necrosis factor-alpha (TNF-alpha) and interleukin-6 (IL-6) promoter polymorphisms confer susceptibility to periodontitis in ethnically different populations. A literature search was performed using PubMed and Embase and a meta-analysis of the identified studies was conducted to explore the associations between TNF-alpha -308 A/G, -238 A/G, IL-6 promoter -174 G/C and -572 G/C polymorphisms and periodontitis. Seventeen comparison studies for the TNF-alpha -308 A/G polymorphism and three studies for the TNF-alpha -238 A/G polymorphism were included in the meta-analysis. And 16 separate studies for the IL-6 -174 G/C polymorphism and 10 studies for the IL-6 -572 G/C polymorphism were considered in our meta-analysis. Analysis after stratification by ethnicity indicated that the TNF-alpha -308 A allele was associated with periodontitis in Brazilian, Asian, and Turkish populations (OR = 0.637, 95 % CI = 0.447-0.907, p = 0.013; OR = 0.403, 95 % CI = 0.204-0.707, p = 0.009; OR = 1.818, 95; % CI = 1.036-3.189, p = 0.037). The meta-analysis showed no association between the TNF-alpha -238 A/G polymorphism and periodontitis. The meta-analysis indicated an association of the IL-6 -174 G/C polymorphisms with periodontitis in Brazilian populations (OR for GG + GC = 2.394, 95 % CI = 1.081-5.302, p = 0.031). Stratification by ethnicity and disease type indicated an association between the IL-6 -572 G allele and chronic periodontitis (OR = 1.585, 95 % CI = 1.030-2.439, p = 0.036), and periodontitis in Europeans (OR = 2.118, 95 % CI = 1.254-3.577, p = 0.005). This meta-analysis demonstrates that the TNF-alpha -308 A/G polymorphism confers susceptibility to periodontitis in Brazilian, Asian and Turkish populations. The IL-6 -174 G/C polymorphism may confer susceptibility to periodontitis in Brazilians, and the IL-6 -572 G/C polymorphism may be associated with susceptibility to periodontitis in Europeans, and chronic periodontitis. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | SPRINGER | - |
dc.subject | SINGLE-NUCLEOTIDE POLYMORPHISMS | - |
dc.subject | RANDOMIZED CONTROLLED-TRIALS | - |
dc.subject | TNF-ALPHA | - |
dc.subject | GENE POLYMORPHISMS | - |
dc.subject | RHEUMATOID-ARTHRITIS | - |
dc.subject | ADULT PERIODONTITIS | - |
dc.subject | CREVICULAR FLUID | - |
dc.subject | IL-6 GENE | - |
dc.subject | SUSCEPTIBILITY | - |
dc.subject | SEVERITY | - |
dc.title | Association between tumor necrosis factor-alpha promoter -308 A/G,-238 A/G, interleukin-6 -174 G/C and -572 G/C polymorphisms and periodontal disease: a meta-analysis | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Song, Gwan Gyu | - |
dc.contributor.affiliatedAuthor | Choi, Sung Jae | - |
dc.contributor.affiliatedAuthor | Ji, Jong Dae | - |
dc.contributor.affiliatedAuthor | Lee, Young Ho | - |
dc.identifier.doi | 10.1007/s11033-013-2621-4 | - |
dc.identifier.scopusid | 2-s2.0-84881142999 | - |
dc.identifier.wosid | 000322392300059 | - |
dc.identifier.bibliographicCitation | MOLECULAR BIOLOGY REPORTS, v.40, no.8, pp.5191 - 5203 | - |
dc.relation.isPartOf | MOLECULAR BIOLOGY REPORTS | - |
dc.citation.title | MOLECULAR BIOLOGY REPORTS | - |
dc.citation.volume | 40 | - |
dc.citation.number | 8 | - |
dc.citation.startPage | 5191 | - |
dc.citation.endPage | 5203 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.subject.keywordPlus | SINGLE-NUCLEOTIDE POLYMORPHISMS | - |
dc.subject.keywordPlus | RANDOMIZED CONTROLLED-TRIALS | - |
dc.subject.keywordPlus | TNF-ALPHA | - |
dc.subject.keywordPlus | GENE POLYMORPHISMS | - |
dc.subject.keywordPlus | RHEUMATOID-ARTHRITIS | - |
dc.subject.keywordPlus | ADULT PERIODONTITIS | - |
dc.subject.keywordPlus | CREVICULAR FLUID | - |
dc.subject.keywordPlus | IL-6 GENE | - |
dc.subject.keywordPlus | SUSCEPTIBILITY | - |
dc.subject.keywordPlus | SEVERITY | - |
dc.subject.keywordAuthor | TNF-alpha | - |
dc.subject.keywordAuthor | IL-6 | - |
dc.subject.keywordAuthor | Polymorphism | - |
dc.subject.keywordAuthor | Periodontitis | - |
dc.subject.keywordAuthor | Meta-analysis | - |
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