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Highly selective and sensitive detection of neurotransmitters using receptor-modified single-walled carbon nanotube sensors

Authors
Kim, ByeongjuSong, Hyun SeokJin, Hye JunPark, Eun JinLee, Sang HunLee, Byung YangPark, Tai HyunHong, Seunghun
Issue Date
19-7월-2013
Publisher
IOP PUBLISHING LTD
Citation
NANOTECHNOLOGY, v.24, no.28
Indexed
SCIE
SCOPUS
Journal Title
NANOTECHNOLOGY
Volume
24
Number
28
URI
https://scholar.korea.ac.kr/handle/2021.sw.korea/102690
DOI
10.1088/0957-4484/24/28/285501
ISSN
0957-4484
Abstract
We present receptor-modified carbon nanotube sensors for the highly selective and sensitive detection of acetylcholine (ACh), one kind of neurotransmitter. Here, we successfully expressed the M1 muscarinic acetylcholine receptor (M1 mAChR), a family of G protein-coupled receptors (GPCRs), in E. coli and coated single-walled carbon nanotube (swCNT)-field effect transistors (FETs) with lipid membrane including the receptor, enabling highly selective and sensitive ACh detection. Using this sensor, we could detect ACh at 100 pM concentration. Moreover, we showed that this sensor could selectively detect ACh among other neurotransmitters. This is the first demonstration of the real-time detection of ACh using specific binding between ACh and M1 mAChR, and it may lead to breakthroughs for various applications such as disease diagnosis and drug screening.
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