Association between ADAM33 S2 and ST+4 polymorphisms and susceptibility to asthma: A meta-analysis
DC Field | Value | Language |
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dc.contributor.author | Song, Gwan Gyu | - |
dc.contributor.author | Kim, Jae-Hoon | - |
dc.contributor.author | Lee, Young Ho | - |
dc.date.accessioned | 2021-09-05T23:47:06Z | - |
dc.date.available | 2021-09-05T23:47:06Z | - |
dc.date.created | 2021-06-14 | - |
dc.date.issued | 2013-07-15 | - |
dc.identifier.issn | 0378-1119 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/102702 | - |
dc.description.abstract | Objective: The aim of this study was to determine whether ADAM33 (a disintegrin and metalloproteinase domain 33) polymorphisms confer susceptibility to asthma in different populations. Methods: We performed a meta-analysis on the association between the ADAM33 52, ST+4, F+1, S1, and V4 polymorphisms and asthma. Results: Thirteen studies in ten reports, which included 4942 patients and 7933 controls, were available for the meta-analysis. Meta-analysis stratified by ethnicity indicated an association between the ADAM33 S2 2 allele and asthma in Europeans (OR = 0.912,95% CI = 0.851-0.977, p = 0.009). Meta-analysis revealed an association between asthma and the ADAM33 ST+4 2 allele (OR = 0.783, 95% CI = 0.762-0.999, p = 0.048). Stratification by ethnicity indicated an association between the ADAM33 ST+4 polymorphism and asthma in Asians. Stratification by age indicated an association between the ADAM33 ST+4 2 allele and asthma in adults (OR = 0.863, 95% CI = 0.782-0.964, p = 0.008). However, no association was found between asthma and the ADAM33 F+1, S1, and V4 polymorphisms. Conclusions: This meta-analysis demonstrates that the ADAM33 S2 polymorphism confers susceptibility to asthma in Europeans and the ADAM33 ST+4 polymorphism is associated with asthma in Asians and adults. (C) 2013 Elsevier B.V. All rights reserved. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | ELSEVIER | - |
dc.subject | GENOME-WIDE ASSOCIATION | - |
dc.subject | GENE POLYMORPHISMS | - |
dc.subject | CHILDHOOD ASTHMA | - |
dc.subject | SEVERITY | - |
dc.subject | IDENTIFICATION | - |
dc.subject | DISINTEGRIN | - |
dc.subject | RHINITIS | - |
dc.title | Association between ADAM33 S2 and ST+4 polymorphisms and susceptibility to asthma: A meta-analysis | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Song, Gwan Gyu | - |
dc.contributor.affiliatedAuthor | Kim, Jae-Hoon | - |
dc.contributor.affiliatedAuthor | Lee, Young Ho | - |
dc.identifier.doi | 10.1016/j.gene.2013.04.023 | - |
dc.identifier.scopusid | 2-s2.0-84878107058 | - |
dc.identifier.wosid | 000320498200010 | - |
dc.identifier.bibliographicCitation | GENE, v.524, no.1, pp.72 - 78 | - |
dc.relation.isPartOf | GENE | - |
dc.citation.title | GENE | - |
dc.citation.volume | 524 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 72 | - |
dc.citation.endPage | 78 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Genetics & Heredity | - |
dc.relation.journalWebOfScienceCategory | Genetics & Heredity | - |
dc.subject.keywordPlus | GENOME-WIDE ASSOCIATION | - |
dc.subject.keywordPlus | GENE POLYMORPHISMS | - |
dc.subject.keywordPlus | CHILDHOOD ASTHMA | - |
dc.subject.keywordPlus | SEVERITY | - |
dc.subject.keywordPlus | IDENTIFICATION | - |
dc.subject.keywordPlus | DISINTEGRIN | - |
dc.subject.keywordPlus | RHINITIS | - |
dc.subject.keywordAuthor | Asthma | - |
dc.subject.keywordAuthor | ADAM33 | - |
dc.subject.keywordAuthor | Polymorphism | - |
dc.subject.keywordAuthor | Meta-analysis | - |
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