Association Between the LCE3C_LCE3B Deletion Polymorphism and Susceptibility to Psoriasis: A Meta-Analysis of Published Studies
DC Field | Value | Language |
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dc.contributor.author | Song, Gwan Gyu | - |
dc.contributor.author | Kim, Jae-Hoon | - |
dc.contributor.author | Lee, Young Ho | - |
dc.date.accessioned | 2021-09-06T00:17:41Z | - |
dc.date.available | 2021-09-06T00:17:41Z | - |
dc.date.created | 2021-06-14 | - |
dc.date.issued | 2013-07 | - |
dc.identifier.issn | 1945-0265 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/102862 | - |
dc.description.abstract | Objective: To determine whether a deletion comprising the LCE3C and LCE3B genes (LCE3C_LCE3B-del) confers susceptibility to psoriasis. Methods: A meta-analysis was conducted to assess the association between the LCE3C_LCE3B-del polymorphism and psoriasis. Results: A total of 12,196 patients with psoriasis and 13,092 controls from 19 comparative studies were included in this meta-analysis. The meta-analysis showed a significant association between psoriasis and the LCE3C_LCE3B-del allele (odds ratio [OR], 1.220; 95% confidence interval [CI], 1.152-1.292; p < 1.0 x 10(-9)). Stratification by ethnicity indicated an association between the LCE3C_LCE3B-del allele and psoriasis in Europeans and Asians (OR, 1.213; 95% CI, 1.130-1.302; p = 8.0 x 10(-9) and OR, 1.260; 95% CI, 1.135-1.398; p = 1.4 x 10(-6), respectively). Analysis using a recessive model, dominant model, and homozygote contrast showed the same pattern for the LCE3C_LCE3B-del allele. The analysis performed in a single Tunisian study showed no association between the LCE3C_LCE3B-del allele and psoriasis. Meta-analysis of the LCE3C_LCE3B-del allele showed no association between psoriatic arthritis and the LCE3C_LCE3B-del polymorphism (OR, 1.087; 95% CI, 0.870-1.359; p = 0.464). Conclusion: Our meta-analysis demonstrates a significant association between psoriasis and the LCE3C_LCE3B-del polymorphism in Europeans and Asians, but no association with psoriatic arthritis. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | MARY ANN LIEBERT, INC | - |
dc.subject | CONVERTING-ENZYME GENE | - |
dc.subject | SYSTEMIC-LUPUS-ERYTHEMATOSUS | - |
dc.subject | INSERTION/DELETION POLYMORPHISM | - |
dc.subject | RHEUMATOID-ARTHRITIS | - |
dc.subject | LCE3C | - |
dc.subject | LOCI | - |
dc.title | Association Between the LCE3C_LCE3B Deletion Polymorphism and Susceptibility to Psoriasis: A Meta-Analysis of Published Studies | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Song, Gwan Gyu | - |
dc.contributor.affiliatedAuthor | Kim, Jae-Hoon | - |
dc.contributor.affiliatedAuthor | Lee, Young Ho | - |
dc.identifier.doi | 10.1089/gtmb.2013.0030 | - |
dc.identifier.scopusid | 2-s2.0-84879940956 | - |
dc.identifier.wosid | 000321243400011 | - |
dc.identifier.bibliographicCitation | GENETIC TESTING AND MOLECULAR BIOMARKERS, v.17, no.7, pp.572 - 577 | - |
dc.relation.isPartOf | GENETIC TESTING AND MOLECULAR BIOMARKERS | - |
dc.citation.title | GENETIC TESTING AND MOLECULAR BIOMARKERS | - |
dc.citation.volume | 17 | - |
dc.citation.number | 7 | - |
dc.citation.startPage | 572 | - |
dc.citation.endPage | 577 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalResearchArea | Genetics & Heredity | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Genetics & Heredity | - |
dc.subject.keywordPlus | CONVERTING-ENZYME GENE | - |
dc.subject.keywordPlus | SYSTEMIC-LUPUS-ERYTHEMATOSUS | - |
dc.subject.keywordPlus | INSERTION/DELETION POLYMORPHISM | - |
dc.subject.keywordPlus | RHEUMATOID-ARTHRITIS | - |
dc.subject.keywordPlus | LCE3C | - |
dc.subject.keywordPlus | LOCI | - |
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