SLCO2B1 genetic polymorphisms in a Korean population: pyrosequencing analyses and comprehensive comparison with other populations
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kim, Kyoung-Ah | - |
dc.contributor.author | Joo, Hyun-Jin | - |
dc.contributor.author | Lee, Hae-Mi | - |
dc.contributor.author | Park, Ji-Young | - |
dc.date.accessioned | 2021-09-06T00:18:51Z | - |
dc.date.available | 2021-09-06T00:18:51Z | - |
dc.date.created | 2021-06-14 | - |
dc.date.issued | 2013-07 | - |
dc.identifier.issn | 0301-4851 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/102870 | - |
dc.description.abstract | SLCO2B1, also known as OATP2B1 (Organic Anion Transporter) or OATP-B or SLC21A9, is an organic anion uptake transporter that is encoded by the SLCO2B1 gene. In this study we assessed the frequencies of SLCO2B1 polymorphisms in a Korean population using newly developed pyrosequencing methods and compared their frequencies with those in other ethnic groups. We developed pyrosequencing methods to identify the following six SLCO2B1 non-synonymous polymorphisms: c.1175C > T (rs1621378), c.1457C > T (rs2306168), c.43C > T (rs56837383), c.935G > A (rs12422149), c.601G > A (rs35199625) and c.644A > T (rs72559740). The allele frequencies of these polymorphisms were analyzed in 227 Korean subjects. The allele frequencies of SLCO2B1 polymorphisms in the population tested were as follows: 0.0 for c.1175C > T, c.43C > T and c.644A > T; 0.2687 for c.1457C > T; 0.4273 for c.935G > A; and 0.0727 for c. 601G > A. Even though the allele frequencies of the c.1175C > T and c.1457C > T polymorphisms were comparable to those in Japanese subjects, the frequencies in this Korean population differed from those in other ethnic groups. The developed pyrosequencing methods are rapid and reliable for detecting non-synonymous SLCO2B1 polymorphisms. Large ethnic differences in the frequency of SLCO2B1 genetic polymorphisms were noted among ethnic groups. The SLCO2B1 polymorphisms at c.1175C > T, c.43C > T and c.644A > T were not found in the Korean population while c.1457C > T, c.935G > A and c.601G > A exhibited mostly higher frequencies in Koreans compared with Finnish, Caucasian and African-American populations. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | SPRINGER | - |
dc.subject | ORGANIC ANION TRANSPORTER | - |
dc.subject | B OATP-B | - |
dc.subject | FUNCTIONAL-CHARACTERIZATION | - |
dc.subject | PHARMACOKINETICS | - |
dc.subject | MONTELUKAST | - |
dc.subject | JUICE | - |
dc.subject | IDENTIFICATION | - |
dc.subject | FREQUENCIES | - |
dc.subject | ABSORPTION | - |
dc.subject | FAMILY | - |
dc.title | SLCO2B1 genetic polymorphisms in a Korean population: pyrosequencing analyses and comprehensive comparison with other populations | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Park, Ji-Young | - |
dc.identifier.doi | 10.1007/s11033-013-2502-x | - |
dc.identifier.scopusid | 2-s2.0-84879337575 | - |
dc.identifier.wosid | 000320674700010 | - |
dc.identifier.bibliographicCitation | MOLECULAR BIOLOGY REPORTS, v.40, no.7, pp.4211 - 4217 | - |
dc.relation.isPartOf | MOLECULAR BIOLOGY REPORTS | - |
dc.citation.title | MOLECULAR BIOLOGY REPORTS | - |
dc.citation.volume | 40 | - |
dc.citation.number | 7 | - |
dc.citation.startPage | 4211 | - |
dc.citation.endPage | 4217 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.subject.keywordPlus | ORGANIC ANION TRANSPORTER | - |
dc.subject.keywordPlus | B OATP-B | - |
dc.subject.keywordPlus | FUNCTIONAL-CHARACTERIZATION | - |
dc.subject.keywordPlus | PHARMACOKINETICS | - |
dc.subject.keywordPlus | MONTELUKAST | - |
dc.subject.keywordPlus | JUICE | - |
dc.subject.keywordPlus | IDENTIFICATION | - |
dc.subject.keywordPlus | FREQUENCIES | - |
dc.subject.keywordPlus | ABSORPTION | - |
dc.subject.keywordPlus | FAMILY | - |
dc.subject.keywordAuthor | SLCO2B1 | - |
dc.subject.keywordAuthor | OATP2B1 | - |
dc.subject.keywordAuthor | Pyrosequencing | - |
dc.subject.keywordAuthor | Pharmacogenetics | - |
dc.subject.keywordAuthor | Koreans | - |
dc.subject.keywordAuthor | Ethnic difference | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
(02841) 서울특별시 성북구 안암로 14502-3290-1114
COPYRIGHT © 2021 Korea University. All Rights Reserved.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.