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Effect of osmotic-release oral system methylphenidate on learning skills in adolescents with attention-deficit/hyperactivity disorder: an open-label study

Authors
Na, Kyoung-SaeLee, Soyoung IreneHong, Sungdo DavidKim, Ji-HoonShim, Se-HoonChoi, JeewookYang, JaewonLee, Moon-SooJoung, Yoo-SookKim, Eui-JungPark, Joon-Ho
Issue Date
7월-2013
Publisher
LIPPINCOTT WILLIAMS & WILKINS
Keywords
adolescents; attention-deficit/hyperactivity disorder; executive function; learning; methylphenidate
Citation
INTERNATIONAL CLINICAL PSYCHOPHARMACOLOGY, v.28, no.4, pp.184 - 192
Indexed
SCIE
SCOPUS
Journal Title
INTERNATIONAL CLINICAL PSYCHOPHARMACOLOGY
Volume
28
Number
4
Start Page
184
End Page
192
URI
https://scholar.korea.ac.kr/handle/2021.sw.korea/102893
DOI
10.1097/YIC.0b013e3283612509
ISSN
0268-1315
Abstract
We evaluated the effect of osmotic-release oral system (OROS) methylphenidate on learning skills in adolescents with attention-deficit/hyperactivity disorder (ADHD). In an open-label study, 121 adolescents with ADHD were administered flexible doses of OROS methylphenidate for 12 weeks. The efficacy of methylphenidate on ADHD symptoms was evaluated by ADHD Rating Scale (ARS) and Clinical Global Impression Scale (CGI). Learning Skills Test (LST) was used to measure the learning skills of the participants at the baseline and the endpoint. Continuous performance test, visuospatial and verbal working memory, verbal fluency, and inhibition were evaluated before and after the 12 weeks of treatment. The mean total and subscores of LST were significantly increased after the 12-week treatment with OROS methylphenidate. Executive functions were also improved during the trial, with the exception of inhibition measured by the Stroop Test. To the best of our knowledge, this is the first study to examine the influence of OROS methylphenidate on learning skill. As a result, OROS methylphenidate was effective in enhancing learning skills in adolescents with ADHD. (C) 2013 Wolters Kluwer Health vertical bar Lippincott Williams & Wilkins.
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