MALDI-TOF Analysis of Polyhexamethylene Guanidine (PHMG) Oligomers Used as a Commercial Antibacterial Humidifier Disinfectant
DC Field | Value | Language |
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dc.contributor.author | Hwang, Hyo Jin | - |
dc.contributor.author | Nam, Jungjoo | - |
dc.contributor.author | Yang, Sung Ik | - |
dc.contributor.author | Kwon, Jung-Hwan | - |
dc.contributor.author | Oh, Han Bin | - |
dc.date.accessioned | 2021-09-06T00:32:19Z | - |
dc.date.available | 2021-09-06T00:32:19Z | - |
dc.date.created | 2021-06-14 | - |
dc.date.issued | 2013-06-20 | - |
dc.identifier.issn | 0253-2964 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/102948 | - |
dc.description.abstract | Polyhexamethylene guanidine (PBMG) polymers used as an active ingredient in an antibacterial humidifier disinfectant were reported to cause harm to the human health when inhaled, although physical contact with this material was known to present low toxicity to humans. It is therefore necessary to develop an optimal analysis method which enables detection and analysis of PHMG polymers. MALDI-TOF investigations of PHMG are performed with a variety of matrices, and it is found that CHCA and 2,5-DHB are excellent matrices which well reflects the polymer population even at high mass. For the provided PHMG sample, the number-average (M-n) and weight-average (M-w) molecular masses were determined to be 744.8 and 810.7, respectively, when the CHCA was used as a matrix. The rank of the matrices in terms of averaged molecular weight was CHCA similar to 2,5-DHB > 5-NSA > DHAP, THAP > ATT > IAA similar to super-DMB similar to HABA. In addition, PSD of the PHMG oligomer ions exhibited a few unique fragmenation characteristics. The formation of a- and c-type fragments was the major fragmentation pathway, and the 25-Da loss peaks generally accompanied a- and c-type fragments. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | WILEY-V C H VERLAG GMBH | - |
dc.subject | LASER-DESORPTION IONIZATION | - |
dc.subject | FLIGHT MASS-SPECTROMETRY | - |
dc.subject | STRUCTURAL-CHARACTERIZATION | - |
dc.subject | ELECTROSPRAY-IONIZATION | - |
dc.subject | MS ANALYSIS | - |
dc.subject | PROTEINS | - |
dc.subject | ACID | - |
dc.subject | GENERATION | - |
dc.subject | BIGUANIDE | - |
dc.subject | EFFICACY | - |
dc.title | MALDI-TOF Analysis of Polyhexamethylene Guanidine (PHMG) Oligomers Used as a Commercial Antibacterial Humidifier Disinfectant | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Kwon, Jung-Hwan | - |
dc.identifier.doi | 10.5012/bkcs.2013.34.6.1708 | - |
dc.identifier.scopusid | 2-s2.0-84879203925 | - |
dc.identifier.wosid | 000321234300019 | - |
dc.identifier.bibliographicCitation | BULLETIN OF THE KOREAN CHEMICAL SOCIETY, v.34, no.6, pp.1708 - 1714 | - |
dc.relation.isPartOf | BULLETIN OF THE KOREAN CHEMICAL SOCIETY | - |
dc.citation.title | BULLETIN OF THE KOREAN CHEMICAL SOCIETY | - |
dc.citation.volume | 34 | - |
dc.citation.number | 6 | - |
dc.citation.startPage | 1708 | - |
dc.citation.endPage | 1714 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.identifier.kciid | ART001775309 | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
dc.relation.journalResearchArea | Chemistry | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Multidisciplinary | - |
dc.subject.keywordPlus | LASER-DESORPTION IONIZATION | - |
dc.subject.keywordPlus | FLIGHT MASS-SPECTROMETRY | - |
dc.subject.keywordPlus | STRUCTURAL-CHARACTERIZATION | - |
dc.subject.keywordPlus | ELECTROSPRAY-IONIZATION | - |
dc.subject.keywordPlus | MS ANALYSIS | - |
dc.subject.keywordPlus | PROTEINS | - |
dc.subject.keywordPlus | ACID | - |
dc.subject.keywordPlus | GENERATION | - |
dc.subject.keywordPlus | BIGUANIDE | - |
dc.subject.keywordPlus | EFFICACY | - |
dc.subject.keywordAuthor | MALDI-TOF | - |
dc.subject.keywordAuthor | Matrix | - |
dc.subject.keywordAuthor | Polyhexamethylene guanidine (PHMG) | - |
dc.subject.keywordAuthor | Polymer | - |
dc.subject.keywordAuthor | Mass spectrometry | - |
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