Peroxiredoxin I is a ROS/p38 MAPK-dependent inducible antioxidant that regulates NF-kappa B-mediated iNOS induction and microglial activation
DC Field | Value | Language |
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dc.contributor.author | Kim, Sun-Uk | - |
dc.contributor.author | Park, Young-Ho | - |
dc.contributor.author | Min, Ju-Sik | - |
dc.contributor.author | Sun, Hu-Nan | - |
dc.contributor.author | Han, Ying-Hao | - |
dc.contributor.author | Hua, Jin-Mei | - |
dc.contributor.author | Lee, Tae-Hoon | - |
dc.contributor.author | Lee, Sang-Rae | - |
dc.contributor.author | Chang, Kyu-Tae | - |
dc.contributor.author | Kang, Sang Won | - |
dc.contributor.author | Kim, Jin-Man | - |
dc.contributor.author | Yu, Dae-Yeul | - |
dc.contributor.author | Lee, Sang-Ho | - |
dc.contributor.author | Lee, Dong-Seok | - |
dc.date.accessioned | 2021-09-06T00:35:59Z | - |
dc.date.available | 2021-09-06T00:35:59Z | - |
dc.date.created | 2021-06-14 | - |
dc.date.issued | 2013-06-15 | - |
dc.identifier.issn | 0165-5728 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/102961 | - |
dc.description.abstract | Reactive oxygen species (ROS) function as modulators of pro-inflammatory processes in microglia-associated neurodegenerative diseases. However, little is known about the involvement of specific antioxidants in regulating the microglial redox status. Here, we demonstrated that peroxiredoxin (Prx) I activity was induced by lipopolysaccharide (LPS), but not paraquat and hydrogen peroxide, through activation of the ROS/p38 MAPK signal pathway, and participated in alleviating the microglial activation and generation of nitric oxide (NO). Interestingly, a null mutation of Prx I accelerated NF-kappa B-mediated iNOS induction and subsequent NO secretion in LPS-stimulated microglia. Furthermore, F4/80 expression as microglial activation marker was notably up-regulated in primary cultures of microglia, hippocampal sections, and cerebral cortex of 15-month-old Prx I-/- mouse. Taken together, the results of our study indicated that Prx I is an antioxidant that is up-regulated in a ROS/p38 MAPK-dependent manner and governs the progression of neuroinflammation by suppressing microglial activation. In addition, Prx I deficiency increased the nuclear translocation of NF-kappa B mediated-iNOS induction as pro-inflammatory mediators. The findings of our work suggest possible strategies for developing novel therapies to treat inflammation-associated degenerative neurological diseases by targeting the induction of Prx I in microglial cells. (c) 2013 Elsevier B.V. All rights reserved. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | ELSEVIER | - |
dc.subject | OXIDATIVE STRESS | - |
dc.subject | REDOX-REGULATION | - |
dc.subject | NITRIC-OXIDE | - |
dc.subject | INFLAMMATORY RESPONSE | - |
dc.subject | ALZHEIMERS-DISEASE | - |
dc.subject | KINASE PATHWAYS | - |
dc.subject | GENE-EXPRESSION | - |
dc.subject | LIPOPOLYSACCHARIDE | - |
dc.subject | CANCER | - |
dc.subject | GENERATION | - |
dc.title | Peroxiredoxin I is a ROS/p38 MAPK-dependent inducible antioxidant that regulates NF-kappa B-mediated iNOS induction and microglial activation | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Lee, Sang-Ho | - |
dc.identifier.doi | 10.1016/j.jneuroim.2013.03.006 | - |
dc.identifier.scopusid | 2-s2.0-84877596486 | - |
dc.identifier.wosid | 000319848100004 | - |
dc.identifier.bibliographicCitation | JOURNAL OF NEUROIMMUNOLOGY, v.259, no.1-2, pp.26 - 36 | - |
dc.relation.isPartOf | JOURNAL OF NEUROIMMUNOLOGY | - |
dc.citation.title | JOURNAL OF NEUROIMMUNOLOGY | - |
dc.citation.volume | 259 | - |
dc.citation.number | 1-2 | - |
dc.citation.startPage | 26 | - |
dc.citation.endPage | 36 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Immunology | - |
dc.relation.journalResearchArea | Neurosciences & Neurology | - |
dc.relation.journalWebOfScienceCategory | Immunology | - |
dc.relation.journalWebOfScienceCategory | Neurosciences | - |
dc.subject.keywordPlus | OXIDATIVE STRESS | - |
dc.subject.keywordPlus | REDOX-REGULATION | - |
dc.subject.keywordPlus | NITRIC-OXIDE | - |
dc.subject.keywordPlus | INFLAMMATORY RESPONSE | - |
dc.subject.keywordPlus | ALZHEIMERS-DISEASE | - |
dc.subject.keywordPlus | KINASE PATHWAYS | - |
dc.subject.keywordPlus | GENE-EXPRESSION | - |
dc.subject.keywordPlus | LIPOPOLYSACCHARIDE | - |
dc.subject.keywordPlus | CANCER | - |
dc.subject.keywordPlus | GENERATION | - |
dc.subject.keywordAuthor | Peroxiredoxin | - |
dc.subject.keywordAuthor | Reactive oxygen species | - |
dc.subject.keywordAuthor | Lipopolysaccharides | - |
dc.subject.keywordAuthor | Inflammation | - |
dc.subject.keywordAuthor | Antioxidants | - |
dc.subject.keywordAuthor | Microglia activation | - |
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