Motor Skill Training Induces Coordinated Strengthening and Weakening between Neighboring Synapses
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Lee, Kea Joo | - |
dc.contributor.author | Park, In Sung | - |
dc.contributor.author | Kim, Hyun | - |
dc.contributor.author | Greenough, William T. | - |
dc.contributor.author | Pak, Daniel T. S. | - |
dc.contributor.author | Rhyu, Im Joo | - |
dc.date.accessioned | 2021-09-06T00:43:24Z | - |
dc.date.available | 2021-09-06T00:43:24Z | - |
dc.date.created | 2021-06-14 | - |
dc.date.issued | 2013-06-05 | - |
dc.identifier.issn | 0270-6474 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/102988 | - |
dc.description.abstract | Motor skill training promotes the formation of parallel fiber multiple-synapse boutons (MSBs) contacting dendritic spine pairs of Purkinje cells in the rat cerebellum. However, the dendritic origin of such spine pairs is unknown. Here, we used three-dimensional electron microscopy reconstruction of synaptic connectivity to demonstrate that motor skill training selectively induced MSBs contacting two spines arising from the same dendrite, consistent with strengthening of local synaptic efficacy. However, excitatory synapses near MSBs were smaller in motor-trained animals, suggesting compensatory depression of MSB-neighbor synapses. Concerted strengthening and weakening of adjacent synapses may enhance synaptic weight differences for information encoding while maintaining stable overall activity levels within local dendritic segments. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | SOC NEUROSCIENCE | - |
dc.subject | LONG-TERM DEPRESSION | - |
dc.subject | HOMEOSTATIC SYNAPTIC PLASTICITY | - |
dc.subject | SERIAL ELECTRON-MICROSCOPY | - |
dc.subject | CEREBELLAR PURKINJE-CELLS | - |
dc.subject | DENDRITIC SPINES | - |
dc.subject | ADULT-RATS | - |
dc.subject | MUTANT MICE | - |
dc.subject | CORTEX | - |
dc.subject | POTENTIATION | - |
dc.subject | NUMBER | - |
dc.title | Motor Skill Training Induces Coordinated Strengthening and Weakening between Neighboring Synapses | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Kim, Hyun | - |
dc.contributor.affiliatedAuthor | Rhyu, Im Joo | - |
dc.identifier.doi | 10.1523/JNEUROSCI.0848-12.2013 | - |
dc.identifier.scopusid | 2-s2.0-84878483661 | - |
dc.identifier.wosid | 000319963300022 | - |
dc.identifier.bibliographicCitation | JOURNAL OF NEUROSCIENCE, v.33, no.23, pp.9794 - 9799 | - |
dc.relation.isPartOf | JOURNAL OF NEUROSCIENCE | - |
dc.citation.title | JOURNAL OF NEUROSCIENCE | - |
dc.citation.volume | 33 | - |
dc.citation.number | 23 | - |
dc.citation.startPage | 9794 | - |
dc.citation.endPage | 9799 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Neurosciences & Neurology | - |
dc.relation.journalWebOfScienceCategory | Neurosciences | - |
dc.subject.keywordPlus | LONG-TERM DEPRESSION | - |
dc.subject.keywordPlus | HOMEOSTATIC SYNAPTIC PLASTICITY | - |
dc.subject.keywordPlus | SERIAL ELECTRON-MICROSCOPY | - |
dc.subject.keywordPlus | CEREBELLAR PURKINJE-CELLS | - |
dc.subject.keywordPlus | DENDRITIC SPINES | - |
dc.subject.keywordPlus | ADULT-RATS | - |
dc.subject.keywordPlus | MUTANT MICE | - |
dc.subject.keywordPlus | CORTEX | - |
dc.subject.keywordPlus | POTENTIATION | - |
dc.subject.keywordPlus | NUMBER | - |
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