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Melanogenesis inhibitory daphnane diterpenoids from the flower buds of Daphne genkwa
- Authors
- Bang, Kwon Ki; Yun, Cheong-Yong; Lee, Chul; Jin, Qinghao; Lee, Jin Woo; Jung, Sang-Hun; Lee, Dongho; Lee, Mi Kyeong; Hong, Jin Tae; Kim, Youngsoo; Hwang, Bang Yeon
- Issue Date
- 1-Jun-2013
- Publisher
- PERGAMON-ELSEVIER SCIENCE LTD
- Keywords
- Daphne genkwa; Thymelaeaceae; Daphnane-type diterpene; Melanogenesis inhibitor
- Citation
- BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, v.23, no.11, pp.3334 - 3337
- Indexed
- SCIE
SCOPUS
- Journal Title
- BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- Volume
- 23
- Number
- 11
- Start Page
- 3334
- End Page
- 3337
- ISSN
- 0960-894X
- Abstract
- Two new daphnane-type diterpene esters, daphneresiniferins A (1) and B (2), along with seven known diterpenes, yuanhuacine (3), yuanhuadine (4), yuanhuahine (5), genkwadaphnin (6), genkwanine A (7), genkwanine F (8), and genkwanine H (9), were isolated from the methanol extract of the flower buds of Daphne genkwa. Their structures were elucidated on the basis of spectroscopic methods, especially 2D NMR spectra such as HMQC, HMBC, and NOESY. All the isolates were evaluated for their inhibitory effects of the melanogenesis against alpha-melanocyte stimulating hormone (alpha-MSH)-activated B16 melanoma cells. (C) 2013 Elsevier Ltd. All rights reserved.
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Related Researcher
- Lee, Dong ho
- Department of Plant Biotechnology