The opposite effect of isotype-selective monoamine oxidase inhibitors on adipogenesis in human bone marrow mesenchymal stem cells
DC Field | Value | Language |
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dc.contributor.author | Byun, Youngjoo | - |
dc.contributor.author | Park, Jongho | - |
dc.contributor.author | Hong, Soo Hyun | - |
dc.contributor.author | Han, Mi Hwa | - |
dc.contributor.author | Park, Suzie | - |
dc.contributor.author | Jung, Hyo-Il | - |
dc.contributor.author | Noh, Minsoo | - |
dc.date.accessioned | 2021-09-06T00:45:25Z | - |
dc.date.available | 2021-09-06T00:45:25Z | - |
dc.date.created | 2021-06-14 | - |
dc.date.issued | 2013-06-01 | - |
dc.identifier.issn | 0960-894X | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/103002 | - |
dc.description.abstract | Adiponectin production during adipocyte differentiation of human bone marrow mesenchymal stem cells (hBM-MSCs) can be used to evaluate the pharmacological activity of anti-diabetic drugs to improve insulin sensitivity. Monoamine oxidase (MAO) inhibitors such as phenelzine and pargyline inhibit adipogenesis in murine pre-adipocytes. In this study, however, we found that selective MAO-A inhibitors, moclobemide and Ro41-1049, and a selective MAO-B inhibitor, selegiline, promoted adiponectin production during adipocyte differentiation in hBM-MSCs, which suggested the anti-diabetic potential of these drugs. In contrast, non-selective MAO inhibitors, phenelzine and tranylcypromine, inhibited adipocyte differentiation of hBM-MSCs. Concomitant treatments of MAO-A and MAO-B selective inhibitors did not change the stimulatory effect on adiponectin production in hBM-MSCs. Taken together, the opposite effects of isotype-selective MAO inhibitors on adiponectin production during adipogenesis in hBM-MSCs may not be directly associated with the inhibitory effects of MAO, suggested that the structure of MAO inhibitors may contain a novel anti-diabetic pharmacophore. (C) 2013 Elsevier Ltd. All rights reserved. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | PERGAMON-ELSEVIER SCIENCE LTD | - |
dc.subject | INSULIN-RESISTANCE | - |
dc.subject | ADIPONECTIN | - |
dc.subject | LEPTIN | - |
dc.subject | RECEPTORS | - |
dc.subject | GAMMA | - |
dc.subject | DRUGS | - |
dc.subject | RATIO | - |
dc.title | The opposite effect of isotype-selective monoamine oxidase inhibitors on adipogenesis in human bone marrow mesenchymal stem cells | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Byun, Youngjoo | - |
dc.identifier.doi | 10.1016/j.bmcl.2013.03.117 | - |
dc.identifier.scopusid | 2-s2.0-84877580770 | - |
dc.identifier.wosid | 000318976100029 | - |
dc.identifier.bibliographicCitation | BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, v.23, no.11, pp.3273 - 3276 | - |
dc.relation.isPartOf | BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | - |
dc.citation.title | BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | - |
dc.citation.volume | 23 | - |
dc.citation.number | 11 | - |
dc.citation.startPage | 3273 | - |
dc.citation.endPage | 3276 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Pharmacology & Pharmacy | - |
dc.relation.journalResearchArea | Chemistry | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Medicinal | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Organic | - |
dc.subject.keywordPlus | INSULIN-RESISTANCE | - |
dc.subject.keywordPlus | ADIPONECTIN | - |
dc.subject.keywordPlus | LEPTIN | - |
dc.subject.keywordPlus | RECEPTORS | - |
dc.subject.keywordPlus | GAMMA | - |
dc.subject.keywordPlus | DRUGS | - |
dc.subject.keywordPlus | RATIO | - |
dc.subject.keywordAuthor | Monoamine oxidase inhibitor | - |
dc.subject.keywordAuthor | Adipogenesis | - |
dc.subject.keywordAuthor | Human mesenchymal stem cells | - |
dc.subject.keywordAuthor | Anti-diabetes | - |
dc.subject.keywordAuthor | Drug repositioning | - |
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