Interferon- gamma release assays versus tuberculin skin testing in patients with rheumatoid arthritis
DC Field | Value | Language |
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dc.contributor.author | Song, Gwan Gyu | - |
dc.contributor.author | Bae, Sang-Cheol | - |
dc.contributor.author | Lee, Young Ho | - |
dc.date.accessioned | 2021-09-06T01:11:14Z | - |
dc.date.available | 2021-09-06T01:11:14Z | - |
dc.date.created | 2021-06-18 | - |
dc.date.issued | 2013-06 | - |
dc.identifier.issn | 1756-1841 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/103131 | - |
dc.description.abstract | ObjectiveThe aim of this study was to analyze the results of interferon-gamma release assays (IGRAs) and tuberculin skin tests (TST) performed to detect latent tuberculosis infection (LTBI) in patients with rheumatoid arthritis (RA). MethodsInterferon- release assays and TST test results were summarized and systematically reviewed. ResultsFour hundred and five RA patients and 339 controls that underwent IGRA and/or TST were identified in seven studies. Five studies were case-control studies and two were cross-sectional studies. Among RA patients, the IGRA positivity rate was 31.6% (89/282; range 11.4%-44.6%), and the TST positivity rate was 23.0% (78/339; range from 14.60% to 45%). Concordance rates ranged from 40% to 76% and discordance rates from 24% to 29.7%. Agreement between IGRAs and TST in RA was poor (69.6%, k=0.33, 95% CI 0.188-0.478). The IGRA positivity rate was 31.0% in RA and 40.0% in controls, which was not significant (relative risk [RR] 0.802, 95% CI 0.629-1.023, P=0.075). The TST positivity rate was 24.7% in RA and 50.5% in controls, and this difference was not significant (RR 0.680, 95% CI 0.331-1.339, P=0.295). ConclusionsPositivity rates of IGRA and TST were 31.6 and 23.0%, respectively, in RA patients. Agreement between IGRA and TST results in RA was poor. Our data suggest that both IGRA and TST are needed to detect LTBI in RA. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | WILEY | - |
dc.subject | LATENT MYCOBACTERIUM-TUBERCULOSIS | - |
dc.subject | INFECTION | - |
dc.subject | POLYMORPHISM | - |
dc.title | Interferon- gamma release assays versus tuberculin skin testing in patients with rheumatoid arthritis | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Lee, Young Ho | - |
dc.identifier.doi | 10.1111/1756-185X.12098 | - |
dc.identifier.scopusid | 2-s2.0-84896059821 | - |
dc.identifier.wosid | 000334521000007 | - |
dc.identifier.bibliographicCitation | INTERNATIONAL JOURNAL OF RHEUMATIC DISEASES, v.16, no.3, pp.279 - 283 | - |
dc.relation.isPartOf | INTERNATIONAL JOURNAL OF RHEUMATIC DISEASES | - |
dc.citation.title | INTERNATIONAL JOURNAL OF RHEUMATIC DISEASES | - |
dc.citation.volume | 16 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 279 | - |
dc.citation.endPage | 283 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Rheumatology | - |
dc.relation.journalWebOfScienceCategory | Rheumatology | - |
dc.subject.keywordPlus | LATENT MYCOBACTERIUM-TUBERCULOSIS | - |
dc.subject.keywordPlus | INFECTION | - |
dc.subject.keywordPlus | POLYMORPHISM | - |
dc.subject.keywordAuthor | interferon-gamma release assays | - |
dc.subject.keywordAuthor | rheumatoid arthritis | - |
dc.subject.keywordAuthor | tuberculin skin tests | - |
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