Angiogenesis imaging in myocardial infarction using Ga-68-NOTA-RGD PET: characterization and application to therapeutic efficacy monitoring in rats
DC Field | Value | Language |
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dc.contributor.author | Eo, Jae Seon | - |
dc.contributor.author | Paeng, Jin Chul | - |
dc.contributor.author | Lee, Song | - |
dc.contributor.author | Lee, Yun-Sang | - |
dc.contributor.author | Jeong, Jae Min | - |
dc.contributor.author | Kang, Keon Wook | - |
dc.contributor.author | Chung, June-Key | - |
dc.contributor.author | Lee, Dong Soo | - |
dc.date.accessioned | 2021-09-06T01:15:39Z | - |
dc.date.available | 2021-09-06T01:15:39Z | - |
dc.date.created | 2021-06-14 | - |
dc.date.issued | 2013-06 | - |
dc.identifier.issn | 0954-6928 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/103159 | - |
dc.description.abstract | Objective Ga-68-NOTA-RGD PET is a newly developed molecular imaging for angiogenesis. In this study, Ga-68-NOTA-RGD PET was used to investigate imaging characteristics in a rat myocardial infarction (MI) model and to monitor the efficacy of an angiogenesis induction therapy. Materials and methods Ga-68-NOTA-RGD PET was performed serially in rats with MI or sham operation, and myocardial uptake was analyzed with respect to time duration and tissue characteristics. Subsequently, Ga-68-NOTA-RGD PET was serially performed for therapeutic efficacy monitoring in MI-induced rats, which were treated with basic fibroblast growth factor (bFGF) injection or saline injection. Image findings were compared with the final change in MI lesion. Results Ga-68-NOTA-RGD uptake was significantly increased in MI lesion and gradually decreased over time. Ga-68-NOTA-RGD uptake in the infarcted tissue corresponded with vascular endothelial growth factor expression and macrophage accumulation. In monitoring of therapeutic efficacy, the lesion uptake in the bFGF-injected group was significantly higher than that of the saline-injected and sham-operated groups on the first day. However, no significant differences were observed between bFGF and saline-injected groups at subsequent time points, corresponding to the final infarct size change. Conclusion Ga-68-NOTA-RGD PET would be a useful angiogenesis imaging modality in MI for assessment of pathophysiology or monitoring of therapeutic efficacy. Coron Artery Dis 24:303-311 (c) 2013 Wolters Kluwer Health vertical bar Lippincott Williams & Wilkins. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | LIPPINCOTT WILLIAMS & WILKINS | - |
dc.subject | FIBROBLAST-GROWTH-FACTOR | - |
dc.subject | ALPHA(V)BETA(3) INTEGRIN EXPRESSION | - |
dc.subject | ISCHEMIC-HEART-DISEASE | - |
dc.subject | MESENCHYMAL STEM-CELLS | - |
dc.subject | DOUBLE-BLIND | - |
dc.subject | DELIVERY | - |
dc.subject | RECEPTOR | - |
dc.subject | AGENT | - |
dc.subject | MODEL | - |
dc.subject | FLOW | - |
dc.title | Angiogenesis imaging in myocardial infarction using Ga-68-NOTA-RGD PET: characterization and application to therapeutic efficacy monitoring in rats | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Eo, Jae Seon | - |
dc.identifier.doi | 10.1097/MCA.0b013e3283608c32 | - |
dc.identifier.scopusid | 2-s2.0-84877048591 | - |
dc.identifier.wosid | 000318154600008 | - |
dc.identifier.bibliographicCitation | CORONARY ARTERY DISEASE, v.24, no.4, pp.303 - 311 | - |
dc.relation.isPartOf | CORONARY ARTERY DISEASE | - |
dc.citation.title | CORONARY ARTERY DISEASE | - |
dc.citation.volume | 24 | - |
dc.citation.number | 4 | - |
dc.citation.startPage | 303 | - |
dc.citation.endPage | 311 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Cardiovascular System & Cardiology | - |
dc.relation.journalWebOfScienceCategory | Cardiac & Cardiovascular Systems | - |
dc.subject.keywordPlus | FIBROBLAST-GROWTH-FACTOR | - |
dc.subject.keywordPlus | ALPHA(V)BETA(3) INTEGRIN EXPRESSION | - |
dc.subject.keywordPlus | ISCHEMIC-HEART-DISEASE | - |
dc.subject.keywordPlus | MESENCHYMAL STEM-CELLS | - |
dc.subject.keywordPlus | DOUBLE-BLIND | - |
dc.subject.keywordPlus | DELIVERY | - |
dc.subject.keywordPlus | RECEPTOR | - |
dc.subject.keywordPlus | AGENT | - |
dc.subject.keywordPlus | MODEL | - |
dc.subject.keywordPlus | FLOW | - |
dc.subject.keywordAuthor | Ga-68 | - |
dc.subject.keywordAuthor | myocardial infarction | - |
dc.subject.keywordAuthor | PET | - |
dc.subject.keywordAuthor | RGD peptide | - |
dc.subject.keywordAuthor | therapeutic angiogenesis | - |
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