T-helper I immunity, specific for the breast cancer antigen insulin-like growth factor-I receptor (IGF-IR), is associated with increased adiposity
DC Field | Value | Language |
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dc.contributor.author | Cecil, Denise L. | - |
dc.contributor.author | Park, Kyong Hwa | - |
dc.contributor.author | Gad, Ekram | - |
dc.contributor.author | Childs, Jennifer S. | - |
dc.contributor.author | Higgins, Doreen M. | - |
dc.contributor.author | Plymate, Stephen R. | - |
dc.contributor.author | Disis, Mary L. | - |
dc.date.accessioned | 2021-09-06T01:20:14Z | - |
dc.date.available | 2021-09-06T01:20:14Z | - |
dc.date.created | 2021-06-14 | - |
dc.date.issued | 2013-06 | - |
dc.identifier.issn | 0167-6806 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/103186 | - |
dc.description.abstract | Numerous lines of evidence demonstrate that breast cancer is immunogenic; yet, there are few biologically relevant immune targets under investigation restricting the exploration of vaccines to limited breast cancer subtypes. Insulin-like growth factor-I receptor (IGF-IR) is a promising vaccine candidate since it is overexpressed in most breast cancer subtypes, is part of a dominant cancer growth pathway, and has been validated as a therapeutic target. We questioned whether IGF-IR was immunogenic in cancer patients. IGF-IR-specific IgG antibodies were significantly elevated in early-stage breast cancer patients at the time of diagnosis as compared to volunteer donors (p = 0.04). Predicted T-helper epitopes, derived from the IGF-IR extracellular and transmembrane domains, elicited a significantly higher incidence of Th2 immunity in breast cancer patients as compared to controls (p = 0.01). Moreover, the magnitude of Th2 immunity was greater in breast cancer patients compared to controls (p = 0.02). In contrast, both breast cancer patients and volunteer donors demonstrated a similar incidence of Th1 immunity to IGF-IR domains with the predominant response directed against epitopes in the intracellular domain of the protein. As the incidence of IGF-IR type I immunity was not associated with a breast cancer diagnosis, we questioned whether other factors were contributing to the presence of IGF-IR-specific T-cells in both populations. While age was not associated with Th1 immunity, we observed a significantly greater magnitude of IGF-IR IFN-gamma-secreting T-cells in obese subjects as compared to overweight (p < 0.001) or healthy-weight (p = 0.006) subjects, regardless of breast cancer diagnosis. No significant difference was observed for Th2 incidence or magnitude when stratified by age (p = 0.174, p = 0.966, respectively) or body mass index (p = 0.137, p = 0.174, respectively). Our data demonstrate that IGF-IR is a tumor antigen and IGF-IR-specific Th1 immunity may be associated with obesity rather than malignancy. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | SPRINGER | - |
dc.subject | B-LYMPHOCYTES | - |
dc.subject | CELLS | - |
dc.subject | CYTOKINE | - |
dc.subject | OBESITY | - |
dc.subject | DIFFERENTIATION | - |
dc.subject | INTERLEUKIN-10 | - |
dc.subject | EXPRESSION | - |
dc.subject | INDUCTION | - |
dc.subject | APOPTOSIS | - |
dc.subject | RESPONSES | - |
dc.title | T-helper I immunity, specific for the breast cancer antigen insulin-like growth factor-I receptor (IGF-IR), is associated with increased adiposity | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Park, Kyong Hwa | - |
dc.identifier.doi | 10.1007/s10549-013-2577-z | - |
dc.identifier.scopusid | 2-s2.0-84879767558 | - |
dc.identifier.wosid | 000321070200004 | - |
dc.identifier.bibliographicCitation | BREAST CANCER RESEARCH AND TREATMENT, v.139, no.3, pp.657 - 665 | - |
dc.relation.isPartOf | BREAST CANCER RESEARCH AND TREATMENT | - |
dc.citation.title | BREAST CANCER RESEARCH AND TREATMENT | - |
dc.citation.volume | 139 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 657 | - |
dc.citation.endPage | 665 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Oncology | - |
dc.relation.journalWebOfScienceCategory | Oncology | - |
dc.subject.keywordPlus | B-LYMPHOCYTES | - |
dc.subject.keywordPlus | CELLS | - |
dc.subject.keywordPlus | CYTOKINE | - |
dc.subject.keywordPlus | OBESITY | - |
dc.subject.keywordPlus | DIFFERENTIATION | - |
dc.subject.keywordPlus | INTERLEUKIN-10 | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordPlus | INDUCTION | - |
dc.subject.keywordPlus | APOPTOSIS | - |
dc.subject.keywordPlus | RESPONSES | - |
dc.subject.keywordAuthor | IGF-IR | - |
dc.subject.keywordAuthor | Breast cancer antigen | - |
dc.subject.keywordAuthor | Th1 | - |
dc.subject.keywordAuthor | Th2 | - |
dc.subject.keywordAuthor | Obesity | - |
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