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Primary breast lymphoma: a single institution's experience

Authors
Jung, Seung PilKim, MinkukHan, Kang MinKim, Jung-HanKim, Jee SooNam, Seok JinBae, Jeoung WonLee, Jeong Eon
Issue Date
5월-2013
Publisher
KOREAN SURGICAL SOCIETY
Keywords
Breast; Diffuse large B-cell lymphoma; Combined modality therapy; Treatment outcome
Citation
JOURNAL OF THE KOREAN SURGICAL SOCIETY, v.84, no.5, pp.267 - 272
Indexed
SCIE
SCOPUS
KCI
Journal Title
JOURNAL OF THE KOREAN SURGICAL SOCIETY
Volume
84
Number
5
Start Page
267
End Page
272
URI
https://scholar.korea.ac.kr/handle/2021.sw.korea/103268
DOI
10.4174/jkss.2013.84.5.267
ISSN
2233-7903
Abstract
Purpose: Primary breast lymphoma is a very rare disease, accounting for 0.4-0.5% of all breast malignancies. Due to the rarity, there are only limited reports of this disease in Korean women. In this reason, we report the experience of a single institution in Korea with primary breast lymphoma (PBL). Methods: We retrospectively reviewed the medical records of 9 patients with PBL and evaluated the clinicopathologic characteristics and treatment outcomes. Results: All nine patients were female and had diffuse large B-cell lymphoma (DLBL). The median age at diagnosis was 47.9 years and the median tumor size was 3.8 cm in diameter. The most common symptom was a painless palpable mass. Five patients were classified as stage IEA and four patients were IIEA according to the Arm Arbor staging system. Four patients underwent excisional biopsy and one patient underwent a lumpectomy with sentinel lymph node biopsy due to uncertain histology of the preoperative core needle biopsy. Nine patients received anthracycline containing combined chemotherapy; among them, five patients were treated with a rituximab containing regimen. Four patients received radiotherapy combined with chemotherapy. A complete response was achieved in eight patients. During the 44 months of the median follow-up period, three cases of relapse occurred, and among them, two patients died due to disease progression. Conclusion: Most PBLs are B-cell origin, with DLBL being the most common histologic type. A combined treatment modality has been known to have positive effects on prognosis, and surgery should be limited to a diagnostic purpose.
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