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Atypical antipsychotics as a possible treatment option for irritable bowel syndrome

Authors
Pae, Chi-UnLee, Soo-JungHan, ChangsuPatkar, Ashwin A.Masand, Prakash S.
Issue Date
5월-2013
Publisher
TAYLOR & FRANCIS LTD
Keywords
anxiety; atypical antipsychotic; depression; irritable bowel syndrome; neurotransmitter
Citation
EXPERT OPINION ON INVESTIGATIONAL DRUGS, v.22, no.5, pp.565 - 572
Indexed
SCIE
SCOPUS
Journal Title
EXPERT OPINION ON INVESTIGATIONAL DRUGS
Volume
22
Number
5
Start Page
565
End Page
572
URI
https://scholar.korea.ac.kr/handle/2021.sw.korea/103292
DOI
10.1517/13543784.2013.782392
ISSN
1354-3784
Abstract
Introduction: Irritable bowel syndrome (IBS) is a prevalent functional gastrointestinal disorder (FGID) that is characterised by chronic abdominal pain, discomfort, bloating, and alteration of bowel habits. Although the pathophysiology of IBS is not fully understood, it is believed that psychiatric comorbidities are highly common in such patients. A variety of psychotropic medications are widely used in the treatment of IBS, particularly older antidepressants such as tricyclic antidepressants (TCAs). Areas covered: With the advent of newer antidepressant classes with better safety and tolerability compared with TCAs, such as serotonin reuptake inhibitors (SSRIs) and serotonin-norepinephrine reuptake inhibitors (SNRIs), clinicians now have more advanced treatment options for treating IBS. Additionally, some atypical antipsychotics (AAs) have recently received approval for treatment of major depressive disorder (MDD). Some AAs may have potentials based on their pharmacodynamic profile and proven benefit for mood symptoms, pain, anxiety and sleep disturbances. This article describes the potential rationale, clinical data and practical aspects involved in the use of AAs for patients with IBS. Expert opinion: Atypical antipsychotics (AAs) may have a role in the treatment of irritable bowel syndrome (IBS) based on the currently available findings, although there is no clear evidence, and a number of clinical issues to be addressed in the use of AAs for the treatment of IBS.
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