Validation of Minor Stroke Definitions for Thrombolysis Decision Making
DC Field | Value | Language |
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dc.contributor.author | Park, Tai Hwan | - |
dc.contributor.author | Hong, Keun-Sik | - |
dc.contributor.author | Choi, Jay Chol | - |
dc.contributor.author | Song, Pamela | - |
dc.contributor.author | Lee, Ji Sung | - |
dc.contributor.author | Lee, Juneyoung | - |
dc.contributor.author | Park, Jong-Moo | - |
dc.contributor.author | Kang, Kyusik | - |
dc.contributor.author | Lee, Kyung Bok | - |
dc.contributor.author | Cho, Yong-Jin | - |
dc.contributor.author | Saposnik, Gustavo | - |
dc.contributor.author | Han, Moon-Ku | - |
dc.contributor.author | Bae, Hee-Joon | - |
dc.date.accessioned | 2021-09-06T01:48:05Z | - |
dc.date.available | 2021-09-06T01:48:05Z | - |
dc.date.created | 2021-06-18 | - |
dc.date.issued | 2013-05 | - |
dc.identifier.issn | 1052-3057 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/103299 | - |
dc.description.abstract | Background: Patients with low National Institutes of Health Stroke Scale (NIHSS) scores are frequently excluded from thrombolysis, but more than 25% of them remain disabled. We sought to define a validated minor stroke definition to reduce the inappropriate treatment exclusion. Methods: From an outcome database, untreated patients with an NIHSS score of 5 or less presenting within a 4.5-hour window were identified and 3-month modified Rankin Scale (mRS) outcomes were analyzed according to individual isolated symptoms and total NIHSS scores. The validity of the following minor stroke definitions were assessed: (1) the National Institute of Neurological Disorders and Stroke Tissue Plasminogen Activator (NINDS-TPA) trials' definition, (2) the total NIHSS score, varying a cutoff point from 0 to 4, and (3) our proposed definition that included an NIHSS score 5 0 or an NIHSS score 5 1 on the items of level of consciousness (LOC), gaze, facial palsy, sensory, or dysarthria. Results: Of 647 patients, 172 patients (26.6%) had a 3-month unfavorable outcome (mRS score 2-6). Favorable outcome was achieved in more than 80% of patients with an NIHSS score of 1 or less or with an isolated symptom on the LOC, gaze, facial palsy, sensory, or dysarthria item. In contrast, unfavorable outcome proportion was more than 25% in patients with an NIHSS score of 2 or more. When the NINDS-TPA trials' definition, our definition, or the definition of an NIHSS score of 1 or less were applied, more than 75% of patients with an unfavorable outcome were defined as a non-minor stroke and less than 15% of patients with an unfavorable outcome were defined as a minor stroke. Conclusion: Implementation of an optimal definition of minor stroke into thrombolysis decision-making process would decrease the unfavorable outcomes in patients with low NIHSS scores. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | ELSEVIER SCIENCE BV | - |
dc.subject | TISSUE-PLASMINOGEN ACTIVATOR | - |
dc.subject | ACUTE ISCHEMIC-STROKE | - |
dc.subject | NEUROLOGICAL-DISORDERS | - |
dc.subject | NATIONAL-INSTITUTE | - |
dc.subject | MILD | - |
dc.subject | OUTCOMES | - |
dc.subject | SYMPTOMS | - |
dc.subject | TRIAL | - |
dc.subject | ELIGIBILITY | - |
dc.subject | GUIDELINES | - |
dc.title | Validation of Minor Stroke Definitions for Thrombolysis Decision Making | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Lee, Juneyoung | - |
dc.identifier.doi | 10.1016/j.jstrokecerebrovasdis.2013.03.006 | - |
dc.identifier.scopusid | 2-s2.0-84877010650 | - |
dc.identifier.wosid | 000318915500032 | - |
dc.identifier.bibliographicCitation | JOURNAL OF STROKE & CEREBROVASCULAR DISEASES, v.22, no.4, pp.482 - 490 | - |
dc.relation.isPartOf | JOURNAL OF STROKE & CEREBROVASCULAR DISEASES | - |
dc.citation.title | JOURNAL OF STROKE & CEREBROVASCULAR DISEASES | - |
dc.citation.volume | 22 | - |
dc.citation.number | 4 | - |
dc.citation.startPage | 482 | - |
dc.citation.endPage | 490 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Neurosciences & Neurology | - |
dc.relation.journalResearchArea | Cardiovascular System & Cardiology | - |
dc.relation.journalWebOfScienceCategory | Neurosciences | - |
dc.relation.journalWebOfScienceCategory | Peripheral Vascular Disease | - |
dc.subject.keywordPlus | TISSUE-PLASMINOGEN ACTIVATOR | - |
dc.subject.keywordPlus | ACUTE ISCHEMIC-STROKE | - |
dc.subject.keywordPlus | NEUROLOGICAL-DISORDERS | - |
dc.subject.keywordPlus | NATIONAL-INSTITUTE | - |
dc.subject.keywordPlus | MILD | - |
dc.subject.keywordPlus | OUTCOMES | - |
dc.subject.keywordPlus | SYMPTOMS | - |
dc.subject.keywordPlus | TRIAL | - |
dc.subject.keywordPlus | ELIGIBILITY | - |
dc.subject.keywordPlus | GUIDELINES | - |
dc.subject.keywordAuthor | Minor stroke definition | - |
dc.subject.keywordAuthor | acute ischemic stroke | - |
dc.subject.keywordAuthor | thrombolysis | - |
dc.subject.keywordAuthor | outcome | - |
dc.subject.keywordAuthor | NINDS-TPA trials | - |
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