Expression pattern and functional role of Phc2 during activation of helper T cells after antigenic stimulation
- Authors
- Cho, Kyu-Won; Bae, Joonbeom; Lee, Suk Jun; Chun, Taehoon
- Issue Date
- 5월-2013
- Publisher
- SPRINGER
- Keywords
- Cell proliferation; IL-2; Helper Tcell; Phc2; Polycomb repressive complex 1
- Citation
- IN VITRO CELLULAR & DEVELOPMENTAL BIOLOGY-ANIMAL, v.49, no.5, pp.360 - 370
- Indexed
- SCIE
SCOPUS
- Journal Title
- IN VITRO CELLULAR & DEVELOPMENTAL BIOLOGY-ANIMAL
- Volume
- 49
- Number
- 5
- Start Page
- 360
- End Page
- 370
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/103416
- DOI
- 10.1007/s11626-013-9618-0
- ISSN
- 1071-2690
- Abstract
- Polycomb group (PcG) proteins, which are conserved from invertebrates to mammals, are associated with epigenetic regulation of many cell fates. The activities of PcG proteins are largely associated with modulation of specific immune reactions. However, no study has attempted to explore the role of Phc2, a subunit of polycomb repressive complex 1, on helper T (Th) cell activation. Presently, Phc2 expression was down-regulated in activated Th cells. The ectopic expression of Phc2 in Th cells inhibited Th cell proliferation and secretion of interleukin-2 from Th cells upon antigen-specific activation. Phc2 may act as a negative regulator that inhibits the activity of Th cells.
- Files in This Item
- There are no files associated with this item.
- Appears in
Collections - Graduate School > Department of Biotechnology > 1. Journal Articles
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.