Relationships Between Exhaled Nitric Oxide and Atopy Profiles in Children With Asthma
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Jang, Won-Nyung | - |
dc.contributor.author | Park, In-Su | - |
dc.contributor.author | Choi, Chang-Hee | - |
dc.contributor.author | Bauer, Siegfried | - |
dc.contributor.author | Harmin, Samuel | - |
dc.contributor.author | Seo, Sung Chul | - |
dc.contributor.author | Choi, Ic Sun | - |
dc.contributor.author | Choung, Ji Tae | - |
dc.contributor.author | Yoo, Young | - |
dc.date.accessioned | 2021-09-06T02:12:56Z | - |
dc.date.available | 2021-09-06T02:12:56Z | - |
dc.date.created | 2021-06-18 | - |
dc.date.issued | 2013-05 | - |
dc.identifier.issn | 2092-7355 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/103424 | - |
dc.description.abstract | Purpose: We examined whether fractional exhaled nitric oxide (FeNO) levels are associated with atopy profiles in terms of mono-sensitization and poly-sensitization in asthmatic children. Methods: A total of 119 children underwent an assessment that included FeNO measurements, spirometry, methacholine challenge, and measurement of blood eosinophil count, serum total IgE, and serum eosinophil cationic protein (ECP). We also examined sensitization to five classes of aeroallergens (house dust mites, animal danders, pollens, molds, and cockroach) using skin prick testing. The children were divided into three groups according to their sensitization profiles to these aeroallergens (non-sensitized, mono-sensitized, and poly-sensitized). Results: The geometric means (range of 1 SD) of FeNO were significantly different between the three groups (non-sensitized, 18.6 ppb [10.0-34.7 ppb]; mono-sensitized, 28.8 ppb [16.6-50.1 ppb]; and poly-sensitized, 44.7 ppb [24.5-81.3 ppb], P=0.001). FeNO levels were correlated with serum total IgE concentrations, peripheral blood eosinophilia, and serum ECP levels to different degrees. Conclusions: FeNO levels vary according to the profile of atopy, as determined by positive skin prick test results to various classes of aeroallergens. FeNO is also moderately correlated with serum total IgE, blood eosinophilia, and serum ECP. These results suggest that poly-sensitized asthmatic children may have the highest risk of airway inflammation. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | KOREAN ACAD ASTHMA ALLERGY & CLINICAL IMMUNOLOGY | - |
dc.subject | SCHOOL-AGE-CHILDREN | - |
dc.subject | RESPONSIVENESS | - |
dc.subject | ALLERGENS | - |
dc.subject | SENSITIZATION | - |
dc.subject | DETERMINANTS | - |
dc.subject | MARKERS | - |
dc.title | Relationships Between Exhaled Nitric Oxide and Atopy Profiles in Children With Asthma | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Seo, Sung Chul | - |
dc.contributor.affiliatedAuthor | Choung, Ji Tae | - |
dc.contributor.affiliatedAuthor | Yoo, Young | - |
dc.identifier.doi | 10.4168/aair.2013.5.3.155 | - |
dc.identifier.scopusid | 2-s2.0-84877114321 | - |
dc.identifier.wosid | 000318194100007 | - |
dc.identifier.bibliographicCitation | ALLERGY ASTHMA & IMMUNOLOGY RESEARCH, v.5, no.3, pp.155 - 161 | - |
dc.relation.isPartOf | ALLERGY ASTHMA & IMMUNOLOGY RESEARCH | - |
dc.citation.title | ALLERGY ASTHMA & IMMUNOLOGY RESEARCH | - |
dc.citation.volume | 5 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 155 | - |
dc.citation.endPage | 161 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.identifier.kciid | ART001761812 | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
dc.description.journalRegisteredClass | other | - |
dc.relation.journalResearchArea | Allergy | - |
dc.relation.journalResearchArea | Immunology | - |
dc.relation.journalWebOfScienceCategory | Allergy | - |
dc.relation.journalWebOfScienceCategory | Immunology | - |
dc.subject.keywordPlus | SCHOOL-AGE-CHILDREN | - |
dc.subject.keywordPlus | RESPONSIVENESS | - |
dc.subject.keywordPlus | ALLERGENS | - |
dc.subject.keywordPlus | SENSITIZATION | - |
dc.subject.keywordPlus | DETERMINANTS | - |
dc.subject.keywordPlus | MARKERS | - |
dc.subject.keywordAuthor | Atopy | - |
dc.subject.keywordAuthor | asthma | - |
dc.subject.keywordAuthor | child | - |
dc.subject.keywordAuthor | fractional exhaled nitric oxide | - |
dc.subject.keywordAuthor | mono-sensitization | - |
dc.subject.keywordAuthor | poly-sensitization | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
145 Anam-ro, Seongbuk-gu, Seoul, 02841, Korea+82-2-3290-2963
COPYRIGHT © 2021 Korea University. All Rights Reserved.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.