Synaptonemal complex protein 3 as a novel prognostic marker in early stage non-small cell lung cancer
DC Field | Value | Language |
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dc.contributor.author | Chung, Joon-Yong | - |
dc.contributor.author | Kitano, Haruhisa | - |
dc.contributor.author | Takikita, Mikiko | - |
dc.contributor.author | Cho, Hanbyoul | - |
dc.contributor.author | Noh, Kyung Hee | - |
dc.contributor.author | Kim, Tae Woo | - |
dc.contributor.author | Ylaya, Kris | - |
dc.contributor.author | Hanaoka, Jun | - |
dc.contributor.author | Fukuoka, Junya | - |
dc.contributor.author | Hewitt, Stephen M. | - |
dc.date.accessioned | 2021-09-06T02:51:25Z | - |
dc.date.available | 2021-09-06T02:51:25Z | - |
dc.date.created | 2021-06-14 | - |
dc.date.issued | 2013-04 | - |
dc.identifier.issn | 0046-8177 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/103581 | - |
dc.description.abstract | Synaptonemal complex protein 3 is a marker for cell transformation that has prognostic significance in various cancers. However, the prognostic significance of synaptonemal complex protein 3 has not been studied in non-small cell lung cancer. To investigate the potential correlation between synaptonemal complex protein 3 and various clinicopathologic parameters, we assessed the expression of synaptonemal complex protein 3 in archival tumor tissues from 258 patients with non-small cell lung cancer by immunohistochemical staining. By immunofluorescence, synaptonemal complex protein 3 was detected in both the cytoplasmic and nuclear fractions of NCI-H1299 cell. In tumor samples, synaptonemal complex protein 3 is detected as cytoplasmic expression pattern and observed in 50 clinical samples (19.4%) by immunohistochemical staining. Synaptonemal complex protein 3 expression was correlated with T status (P = .008), lymph node metastasis (P = .010), tumor types (P = .019), and pleural invasion (P = .005). In multivariate analysis of patients with early stage disease, increased synaptonemal complex protein 3 expression predicted worse overall survival in early stage (stage I and II) with pT1 status (P = .041). These results suggest that positive synaptonemal complex protein 3 expression is a portent of poor outcome and may be a potential biomarker in the early stages of the non-small cell lung cancer for survival and may provide clues in the identification of patients for adjuvant therapy. Published by Elsevier Inc. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | W B SAUNDERS CO-ELSEVIER INC | - |
dc.subject | BIOMARKERS | - |
dc.subject | OVEREXPRESSION | - |
dc.subject | LOCALIZATION | - |
dc.subject | EXPRESSION | - |
dc.subject | DIAGNOSIS | - |
dc.subject | SYCP3 | - |
dc.subject | CORE | - |
dc.title | Synaptonemal complex protein 3 as a novel prognostic marker in early stage non-small cell lung cancer | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Noh, Kyung Hee | - |
dc.contributor.affiliatedAuthor | Kim, Tae Woo | - |
dc.identifier.doi | 10.1016/j.humpath.2012.06.018 | - |
dc.identifier.scopusid | 2-s2.0-84875231299 | - |
dc.identifier.wosid | 000317246700002 | - |
dc.identifier.bibliographicCitation | HUMAN PATHOLOGY, v.44, no.4, pp.472 - 479 | - |
dc.relation.isPartOf | HUMAN PATHOLOGY | - |
dc.citation.title | HUMAN PATHOLOGY | - |
dc.citation.volume | 44 | - |
dc.citation.number | 4 | - |
dc.citation.startPage | 472 | - |
dc.citation.endPage | 479 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Pathology | - |
dc.relation.journalWebOfScienceCategory | Pathology | - |
dc.subject.keywordPlus | BIOMARKERS | - |
dc.subject.keywordPlus | OVEREXPRESSION | - |
dc.subject.keywordPlus | LOCALIZATION | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordPlus | DIAGNOSIS | - |
dc.subject.keywordPlus | SYCP3 | - |
dc.subject.keywordPlus | CORE | - |
dc.subject.keywordAuthor | Immunohistochemistry | - |
dc.subject.keywordAuthor | Non-small cell lung cancer | - |
dc.subject.keywordAuthor | Prognostic marker | - |
dc.subject.keywordAuthor | Synaptonemal complex protein 3 | - |
dc.subject.keywordAuthor | Tissue microarray | - |
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