EGFR Gene Amplification and Protein Expression in Invasive Ductal Carcinoma of the Breast
DC Field | Value | Language |
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dc.contributor.author | Hwangbo, Won | - |
dc.contributor.author | Lee, Jeong Hyeon | - |
dc.contributor.author | Ahn, Sangjeong | - |
dc.contributor.author | Kim, Seojin | - |
dc.contributor.author | Park, Kyong Hwa | - |
dc.contributor.author | Kim, Chul Hwan | - |
dc.contributor.author | Kim, Insun | - |
dc.date.accessioned | 2021-09-06T03:09:38Z | - |
dc.date.available | 2021-09-06T03:09:38Z | - |
dc.date.created | 2021-06-14 | - |
dc.date.issued | 2013-04 | - |
dc.identifier.issn | 1738-1843 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/103658 | - |
dc.description.abstract | Background: The epidermal growth factor receptor (EGFR) is a surrogate marker for basal-like breast cancer. A recent study suggested that EGFR may be used as a target for breast cancer treatment. Methods: A total of 706 invasive ductal carcinomas (IDC) of the breast were immunophenotyped, and 82 cases with EGFR protein expression were studied for EGFR gene amplification. Results: EGFR protein was expressed in 121 of 706 IDCs (17.1%); 5.9% were of luminal type, 25.3% of epidermal growth factor receptor 2 (HER-2) type, and 79.3% of basal-like tumors. EGFR gene amplification and high polysomy (fluorescent in situ hybridization [FISH]-positive) were found in 18 of 82 cases (22.0%); 41.2% of the HER-2(+), EGFR(+), cytokeratin 5/6(-) (CK5/6(-)) group, 11.2% of the HER-2(-), EGFR(+), CK5/6(-) group, and 19.1% of the HER-2(-), EGFR(+), CK5/6(+) group. FISH-positive cases were detected in 8.3% of the EGFR protein 1(+) expression cases, 15.9% of 2(+) expression cases, and 38.5% of 3(+) expression cases. In group 2, the tumors had a high Ki-67 labeling (>60%), but the patients showed better disease-free survival than those with tumors that co-expressed HER-2 or CK5/6. Conclusions: EGFR-directed therapy can be considered in breast cancer patients with EGFR protein overexpression and gene amplification, and its therapeutic implication should be determined in HER-2 type breast cancer patients. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | KOREAN SOCIETY PATHOLOGISTS | - |
dc.subject | GROWTH-FACTOR RECEPTOR | - |
dc.subject | CELL LUNG-CANCER | - |
dc.subject | COPY NUMBER | - |
dc.subject | OVEREXPRESSION | - |
dc.subject | CHEMOTHERAPY | - |
dc.subject | PREDICTS | - |
dc.subject | FEATURES | - |
dc.subject | HER2 | - |
dc.title | EGFR Gene Amplification and Protein Expression in Invasive Ductal Carcinoma of the Breast | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Park, Kyong Hwa | - |
dc.contributor.affiliatedAuthor | Kim, Chul Hwan | - |
dc.contributor.affiliatedAuthor | Kim, Insun | - |
dc.identifier.doi | 10.4132/KoreanJPathol.2013.47.2.107 | - |
dc.identifier.scopusid | 2-s2.0-84879207204 | - |
dc.identifier.wosid | 000318384400003 | - |
dc.identifier.bibliographicCitation | KOREAN JOURNAL OF PATHOLOGY, v.47, no.2, pp.107 - 115 | - |
dc.relation.isPartOf | KOREAN JOURNAL OF PATHOLOGY | - |
dc.citation.title | KOREAN JOURNAL OF PATHOLOGY | - |
dc.citation.volume | 47 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 107 | - |
dc.citation.endPage | 115 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.identifier.kciid | ART001764787 | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
dc.relation.journalResearchArea | Pathology | - |
dc.relation.journalWebOfScienceCategory | Pathology | - |
dc.subject.keywordPlus | GROWTH-FACTOR RECEPTOR | - |
dc.subject.keywordPlus | CELL LUNG-CANCER | - |
dc.subject.keywordPlus | COPY NUMBER | - |
dc.subject.keywordPlus | OVEREXPRESSION | - |
dc.subject.keywordPlus | CHEMOTHERAPY | - |
dc.subject.keywordPlus | PREDICTS | - |
dc.subject.keywordPlus | FEATURES | - |
dc.subject.keywordPlus | HER2 | - |
dc.subject.keywordAuthor | Breast neoplasms | - |
dc.subject.keywordAuthor | Receptor, epidermal growth factor | - |
dc.subject.keywordAuthor | Gene amplification | - |
dc.subject.keywordAuthor | Protein expression | - |
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