The CTLA-4 +49 A/G, CT60 A/G and PTPN22 1858 C/T polymorphisms and susceptibility to vitiligo: a meta-analysis
DC Field | Value | Language |
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dc.contributor.author | Song, Gwan Gyu | - |
dc.contributor.author | Kim, Jae-Hoon | - |
dc.contributor.author | Lee, Young Ho | - |
dc.date.accessioned | 2021-09-06T03:15:16Z | - |
dc.date.available | 2021-09-06T03:15:16Z | - |
dc.date.created | 2021-06-14 | - |
dc.date.issued | 2013-04 | - |
dc.identifier.issn | 0301-4851 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/103690 | - |
dc.description.abstract | The aim of this study was to explore whether cytotoxic T lymphocyte antigen-4 (CTLA-4) +49 A/G, CT60 A/G, and protein tyrosine phosphatase nonreceptor 22 (PTPN22) 1858 C/T polymorphisms confer susceptibility to vitiligo. A meta-analysis was conducted of the associations between the CTLA-4 +49 A/G, CT60 and PTPN22 1858 C/T polymorphisms and vitiligo using; (1) allele contrast, (2) the recessive model, (3) the dominant model, and (4) the additive model. A total of 14 separate comparisons were considered in our meta-analysis consisting of 3,404 patients with vitiligo and 5,069 controls (nine studies with 1,252 cases and 2,152 controls for the CTLA-4 polymorphisms and five studies with 1,800 cases and 3,269 controls for the PTPN22 polymorphism). Meta-analysis showed no association between vitiligo and the CTLA-4 +49 A/G polymorphism in all study subjects (OR of the G allele = 1.186, 95 % CI = 0.893-1.575, p = 0.240) and in European (OR = 1.016, 95 % CI = 0.873-1.182, p = 0.838). However, meta-analysis of the CTLA-4 CT60 A/G polymorphism showed an association between vitiligo and the CTLA-4 CT60 G allele in all study subjects (OR = 1.267, 95 % CI = 1.110-1.447, p = 4.5 x 10(-5)) and in the European group (OR = 1.345, 95 % CI = 1.163-1.556, p = 6.3 x 10(-6)). Analysis using the recessive model and homozygote contrast showed the same pattern for the CTLA-4 CT60 G allele. Meta-analysis of the PTPN22 1858 C/T polymorphism showed an association between the PTPN22 T allele and vitiligo in all subjects (OR = 1.507, 95 % CI = 1.320-1.720, p < 1.0 x 10(-8)) and in European group (OR = 1.530, 95 % CI = 1.339-1.748, p < 1.0 x 10(-8)), but not in Asians (OR = 0.482, 95 % CI = 0.152-1.530, p = 0.216). Analysis using the recessive, dominant model, and homozygote contrast showed the same pattern for the PTPN22 T allele. This meta-analysis demonstrates that the CTLA-4 CT60 A/G polymorphism confers susceptibility to vitiligo in Europeans, but no association was found between the CTLA-4 +49 A/G polymorphism and vitiligo susceptibility. The PTPN22 C1858T polymorphism is associated with vitiligo susceptibility in European population. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | SPRINGER | - |
dc.subject | SINGLE-NUCLEOTIDE POLYMORPHISM | - |
dc.subject | PROTEIN-TYROSINE-PHOSPHATASE | - |
dc.subject | SYSTEMIC-LUPUS-ERYTHEMATOSUS | - |
dc.subject | GENERALIZED VITILIGO | - |
dc.subject | RHEUMATOID-ARTHRITIS | - |
dc.subject | FUNCTIONAL POLYMORPHISM | - |
dc.subject | AUTOIMMUNE-DISEASES | - |
dc.subject | T-CELLS | - |
dc.subject | PTPN22 | - |
dc.subject | GENE | - |
dc.title | The CTLA-4 +49 A/G, CT60 A/G and PTPN22 1858 C/T polymorphisms and susceptibility to vitiligo: a meta-analysis | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Song, Gwan Gyu | - |
dc.contributor.affiliatedAuthor | Kim, Jae-Hoon | - |
dc.contributor.affiliatedAuthor | Lee, Young Ho | - |
dc.identifier.doi | 10.1007/s11033-012-2370-9 | - |
dc.identifier.scopusid | 2-s2.0-84878419695 | - |
dc.identifier.wosid | 000316221100025 | - |
dc.identifier.bibliographicCitation | MOLECULAR BIOLOGY REPORTS, v.40, no.4, pp.2985 - 2993 | - |
dc.relation.isPartOf | MOLECULAR BIOLOGY REPORTS | - |
dc.citation.title | MOLECULAR BIOLOGY REPORTS | - |
dc.citation.volume | 40 | - |
dc.citation.number | 4 | - |
dc.citation.startPage | 2985 | - |
dc.citation.endPage | 2993 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.subject.keywordPlus | SINGLE-NUCLEOTIDE POLYMORPHISM | - |
dc.subject.keywordPlus | PROTEIN-TYROSINE-PHOSPHATASE | - |
dc.subject.keywordPlus | SYSTEMIC-LUPUS-ERYTHEMATOSUS | - |
dc.subject.keywordPlus | GENERALIZED VITILIGO | - |
dc.subject.keywordPlus | RHEUMATOID-ARTHRITIS | - |
dc.subject.keywordPlus | FUNCTIONAL POLYMORPHISM | - |
dc.subject.keywordPlus | AUTOIMMUNE-DISEASES | - |
dc.subject.keywordPlus | T-CELLS | - |
dc.subject.keywordPlus | PTPN22 | - |
dc.subject.keywordPlus | GENE | - |
dc.subject.keywordAuthor | Vitiligo | - |
dc.subject.keywordAuthor | Cytotoxic T lymphocyte antigen-4 | - |
dc.subject.keywordAuthor | PTPN22 | - |
dc.subject.keywordAuthor | Polymorphism | - |
dc.subject.keywordAuthor | Meta-analysis | - |
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