Detailed Information
Cited 0 time in 
Cited 0 time in 
Cited 0 time in
Metadata Downloads
Synthesis and biological evaluation of 1-(2-hydroxy-3-phenyloxypropyl)piperazine derivatives as T-type calcium channel blockers
Full metadata record
| DC Field | Value | Language |
|---|---|---|
| dc.contributor.author | Park, Jung-eun | - |
| dc.contributor.author | Ji, Wan Keun | - |
| dc.contributor.author | Jang, Jae Wan | - |
| dc.contributor.author | Pae, Ae Nim | - |
| dc.contributor.author | Choi, Keehyun | - |
| dc.contributor.author | Choi, Ki Hang | - |
| dc.contributor.author | Kang, Jahyo | - |
| dc.contributor.author | Roh, Eun Joo | - |
| dc.date.accessioned | 2021-09-06T03:28:37Z | - |
| dc.date.available | 2021-09-06T03:28:37Z | - |
| dc.date.created | 2021-06-14 | - |
| dc.date.issued | 2013-03-15 | - |
| dc.identifier.issn | 0960-894X | - |
| dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/103739 | - |
| dc.description.abstract | To obtain selective and potent inhibitor for T-type calcium channel by ligand based drug design, 2-hydroxy-3-phenoxypropyl piperazine derivatives were synthesized and evaluated for in vitro activities. Compound 6m and 6q showed high selectivity over hERG channel (IC50 ratio of hERG/alpha(1G) 6m = 8.5, 6q = 18.38) and they were subjected to measure pharmacokinetics profiles. Among them compound 6m showed an excellent pharmacokinetic profile in rats. (C) 2013 Elsevier Ltd. All rights reserved. | - |
| dc.language | English | - |
| dc.language.iso | en | - |
| dc.publisher | PERGAMON-ELSEVIER SCIENCE LTD | - |
| dc.subject | CA2+ CHANNELS | - |
| dc.subject | INHIBITION | - |
| dc.subject | TARGETS | - |
| dc.title | Synthesis and biological evaluation of 1-(2-hydroxy-3-phenyloxypropyl)piperazine derivatives as T-type calcium channel blockers | - |
| dc.type | Article | - |
| dc.contributor.affiliatedAuthor | Choi, Ki Hang | - |
| dc.identifier.doi | 10.1016/j.bmcl.2012.12.072 | - |
| dc.identifier.scopusid | 2-s2.0-84874654558 | - |
| dc.identifier.wosid | 000315331500065 | - |
| dc.identifier.bibliographicCitation | BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, v.23, no.6, pp.1887 - 1890 | - |
| dc.relation.isPartOf | BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | - |
| dc.citation.title | BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | - |
| dc.citation.volume | 23 | - |
| dc.citation.number | 6 | - |
| dc.citation.startPage | 1887 | - |
| dc.citation.endPage | 1890 | - |
| dc.type.rims | ART | - |
| dc.type.docType | Article | - |
| dc.description.journalClass | 1 | - |
| dc.description.journalRegisteredClass | scie | - |
| dc.description.journalRegisteredClass | scopus | - |
| dc.relation.journalResearchArea | Pharmacology & Pharmacy | - |
| dc.relation.journalResearchArea | Chemistry | - |
| dc.relation.journalWebOfScienceCategory | Chemistry, Medicinal | - |
| dc.relation.journalWebOfScienceCategory | Chemistry, Organic | - |
| dc.subject.keywordPlus | CA2+ CHANNELS | - |
| dc.subject.keywordPlus | INHIBITION | - |
| dc.subject.keywordPlus | TARGETS | - |
- Files in This Item
- There are no files associated with this item.
- Appears in
Collections - College of Science > Department of Chemistry > 1. Journal Articles
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.