Role of dopamine D2 receptors in plasticity of stress-induced addictive behaviours
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Sim, Hye-ri | - |
dc.contributor.author | Choi, Tae-Yong | - |
dc.contributor.author | Lee, Hyo Jin | - |
dc.contributor.author | Kang, Eun Young | - |
dc.contributor.author | Yoon, Sehyoun | - |
dc.contributor.author | Han, Pyung-Lim | - |
dc.contributor.author | Choi, Se-Young | - |
dc.contributor.author | Baik, Ja-Hyun | - |
dc.date.accessioned | 2021-09-06T03:48:54Z | - |
dc.date.available | 2021-09-06T03:48:54Z | - |
dc.date.created | 2021-06-14 | - |
dc.date.issued | 2013-03 | - |
dc.identifier.issn | 2041-1723 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/103807 | - |
dc.description.abstract | Dopaminergic systems are implicated in stress-related behaviour. Here we investigate behavioural responses to chronic stress in dopamine D2 receptor knockout mice and find that anxiety-like behaviours are increased compared with wild-type mice. Repeated stress exposure suppresses cocaine-induced behavioural sensitization, cocaine-seeking and relapse behaviours in dopamine D2 receptor knockout mice. Cocaine challenge after drug withdrawal in cocaine-experienced wild-type or dopamine D2 receptor knockout mice is associated with inhibition of long-term depression in the nucleus accumbens, and chronic stress during withdrawal prevents inhibition after cocaine challenge in cocaine-experienced dopamine D2 receptor knockout mice, but not in wild-type mice. Lentiviral-induced knockdown of dopamine D2 receptors in the nucleus accumbens of wild-type mice does not affect basal locomotor activity, but confers stress-induced inhibition of the expression of cocaine-induced behavioural sensitization. Stressed mice depleted of dopamine D2 receptors do not manifest long-term depression inhibition. Our results suggest that dopamine D2 receptors have roles in regulating synaptic modification triggered by stress and drug addiction. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | NATURE PUBLISHING GROUP | - |
dc.subject | SIGNAL-REGULATED KINASE | - |
dc.subject | NUCLEUS-ACCUMBENS | - |
dc.subject | SYNAPTIC PLASTICITY | - |
dc.subject | GLUTAMATERGIC TRANSMISSION | - |
dc.subject | COCAINE-SEEKING | - |
dc.subject | KNOCKOUT MICE | - |
dc.subject | REWARD | - |
dc.subject | SENSITIZATION | - |
dc.subject | DEPRESSION | - |
dc.subject | SYSTEM | - |
dc.title | Role of dopamine D2 receptors in plasticity of stress-induced addictive behaviours | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Baik, Ja-Hyun | - |
dc.identifier.doi | 10.1038/ncomms2598 | - |
dc.identifier.scopusid | 2-s2.0-84875836000 | - |
dc.identifier.wosid | 000318873900033 | - |
dc.identifier.bibliographicCitation | NATURE COMMUNICATIONS, v.4 | - |
dc.relation.isPartOf | NATURE COMMUNICATIONS | - |
dc.citation.title | NATURE COMMUNICATIONS | - |
dc.citation.volume | 4 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Science & Technology - Other Topics | - |
dc.relation.journalWebOfScienceCategory | Multidisciplinary Sciences | - |
dc.subject.keywordPlus | SIGNAL-REGULATED KINASE | - |
dc.subject.keywordPlus | NUCLEUS-ACCUMBENS | - |
dc.subject.keywordPlus | SYNAPTIC PLASTICITY | - |
dc.subject.keywordPlus | GLUTAMATERGIC TRANSMISSION | - |
dc.subject.keywordPlus | COCAINE-SEEKING | - |
dc.subject.keywordPlus | KNOCKOUT MICE | - |
dc.subject.keywordPlus | REWARD | - |
dc.subject.keywordPlus | SENSITIZATION | - |
dc.subject.keywordPlus | DEPRESSION | - |
dc.subject.keywordPlus | SYSTEM | - |
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