Associations between interleukin-10 polymorphisms and susceptibility to systemic lupus erythematosus: A meta-analysis
DC Field | Value | Language |
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dc.contributor.author | Song, Gwan Gyu | - |
dc.contributor.author | Choi, Sung Jae | - |
dc.contributor.author | Ji, Jong Dae | - |
dc.contributor.author | Lee, Young Ho | - |
dc.date.accessioned | 2021-09-06T04:14:52Z | - |
dc.date.available | 2021-09-06T04:14:52Z | - |
dc.date.created | 2021-06-14 | - |
dc.date.issued | 2013-03 | - |
dc.identifier.issn | 0198-8859 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/103929 | - |
dc.description.abstract | Objective: The study determined whether interleukin-10 (IL-10) polymorphisms confer susceptibility to systemic lupus erythematosus (SLE). Methods: A meta-analysis was conducted on the associations between the IL-10-1082 G/A, -819 C/T, -592 C/A polymorphisms and the haplotype of the IL-10-1082 G/A, -819 C/T, -592 C/A polymorphisms and SLE. Results: A total of 19 studies involving 2828 SLE patients and 4008 controls were considered in the meta-analysis. Meta-analysis of the IL-10-1082 G/A polymorphism revealed an association between SLE and the IL-10-1082 G allele (odds ratio [OR] = 1.158, 95% confidence interval [CI] = 1.051-1.276, p = 0.003). Stratification by ethnicity indicated an association between the IL-10-1082 G allele and SLE in Europeans (OR = 1.160, 95% CI = 1.039-1.296, p = 0.008). Meta-analysis stratified by ethnicity produced an association between the IL-10-819 C allele and SLE in Asians (OR=1.308, 95% CI = 1.030-1.619, p = 0.027). Meta-analysis of the homozygous GCC/GCC haplotype failed to show a significant association with SLE in Europeans (OR=1.223,95% CI = 0.981-1.526, p = 0.074). However, meta-analysis of the GCC haplotype revealed a significant association with RA in all study subjects (OR = 1.402, 95% CI = 1.001-1.964, p = 0.049). Stratification by ethnicity indicated an association between the GCC haplotype and SLE in Europeans (OR = 1.656, 95% CI = 1.087-2.523, p = 0.019), but not in Asians (OR = 1.100, 95% CI = 0.703-1.721, p = 0.677). Meta-analysis of homozygous ATA/ATA haplotype failed to show a significant association with SLE in overall and European groups. However, meta-analysis of the ATA haplotype revealed a significant association with SLE in all study subjects (OR=1.516, 95% CI=1.039-2.213, p = 0.031) and Asians (OR = 2.580, 95% CI = 2.086-3.192, p<1 x 10(-9)), but not in Europeans (OR = 1.233, 95% CI = 0.816-1.862, p = 0.320). Conclusions: This meta-analysis suggests that the IL-10 polymorphisms confer susceptibility to SLE in Europeans and in Asians. (C) 2012 American Society for Histocompatibility and Immunogenetics. Published by Elsevier Inc. All rights reserved. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | ELSEVIER SCIENCE INC | - |
dc.subject | SINGLE-NUCLEOTIDE POLYMORPHISMS | - |
dc.subject | GENOME SCAN METAANALYSIS | - |
dc.subject | GAMMA RECEPTOR IIA | - |
dc.subject | PROMOTER POLYMORPHISMS | - |
dc.subject | RHEUMATOID-ARTHRITIS | - |
dc.subject | GENE PROMOTER | - |
dc.subject | CHINESE PATIENTS | - |
dc.subject | RENAL-DISEASE | - |
dc.subject | IL-10 | - |
dc.subject | RISK | - |
dc.title | Associations between interleukin-10 polymorphisms and susceptibility to systemic lupus erythematosus: A meta-analysis | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Song, Gwan Gyu | - |
dc.contributor.affiliatedAuthor | Choi, Sung Jae | - |
dc.contributor.affiliatedAuthor | Ji, Jong Dae | - |
dc.contributor.affiliatedAuthor | Lee, Young Ho | - |
dc.identifier.doi | 10.1016/j.humimm.2012.11.020 | - |
dc.identifier.scopusid | 2-s2.0-84873705918 | - |
dc.identifier.wosid | 000315613800015 | - |
dc.identifier.bibliographicCitation | HUMAN IMMUNOLOGY, v.74, no.3, pp.364 - 370 | - |
dc.relation.isPartOf | HUMAN IMMUNOLOGY | - |
dc.citation.title | HUMAN IMMUNOLOGY | - |
dc.citation.volume | 74 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 364 | - |
dc.citation.endPage | 370 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Immunology | - |
dc.relation.journalWebOfScienceCategory | Immunology | - |
dc.subject.keywordPlus | SINGLE-NUCLEOTIDE POLYMORPHISMS | - |
dc.subject.keywordPlus | GENOME SCAN METAANALYSIS | - |
dc.subject.keywordPlus | GAMMA RECEPTOR IIA | - |
dc.subject.keywordPlus | PROMOTER POLYMORPHISMS | - |
dc.subject.keywordPlus | RHEUMATOID-ARTHRITIS | - |
dc.subject.keywordPlus | GENE PROMOTER | - |
dc.subject.keywordPlus | CHINESE PATIENTS | - |
dc.subject.keywordPlus | RENAL-DISEASE | - |
dc.subject.keywordPlus | IL-10 | - |
dc.subject.keywordPlus | RISK | - |
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