Implication of Progranulin and C1q/TNF-Related Protein-3 (CTRP3) on Inflammation and Atherosclerosis in Subjects with or without Metabolic Syndrome
DC Field | Value | Language |
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dc.contributor.author | Yoo, Hye Jin | - |
dc.contributor.author | Hwang, Soon Young | - |
dc.contributor.author | Hong, Ho Cheol | - |
dc.contributor.author | Choi, Hae Yoon | - |
dc.contributor.author | Yang, Sae Jeong | - |
dc.contributor.author | Choi, Dong Seop | - |
dc.contributor.author | Baik, Sei Hyun | - |
dc.contributor.author | Blueher, Matthias | - |
dc.contributor.author | Youn, Byung-Soo | - |
dc.contributor.author | Choi, Kyung Mook | - |
dc.date.accessioned | 2021-09-06T04:28:31Z | - |
dc.date.available | 2021-09-06T04:28:31Z | - |
dc.date.created | 2021-06-14 | - |
dc.date.issued | 2013-02-07 | - |
dc.identifier.issn | 1932-6203 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/103974 | - |
dc.description.abstract | Objective: Progranulin and C1q/TNF-related protein-3 (CTRP3) were recently discovered as novel adipokines which may link obesity with altered regulation of glucose metabolism, chronic inflammation and insulin resistance. Research Design and Methods: We examined circulating progranulin and CTRP3 concentrations in 127 subjects with (n = 44) or without metabolic syndrome (n = 83). Furthermore, we evaluated the relationship of progranulin and CTRP3 levels with inflammatory markers and cardiometabolic risk factors, including high-sensitivity C-reactive protein (hsCRP), interleukin-6 (IL-6), estimated glomerular filtration rate (eGFR), and adiponectin serum concentrations, as well as carotid intima-media thickness (CIMT). Results: Circulating progranulin levels are significantly related with inflammatory markers, hsCRP (r = 0.30, P = 0.001) and IL-6 (r = 0.30, P = 0.001), whereas CTRP3 concentrations exhibit a significant association with cardiometabolic risk factors, including waist circumference (r = -0.21), diastolic blood pressure (r = -0.21), fasting glucose (r = -0.20), triglyceride (r = -0.34), total cholesterol (r = -0.25), eGFR (r = 0.39) and adiponectin (r = 0.26) levels. Serum progranulin concentrations were higher in patients with metabolic syndrome than those of the control group (199.55 [179.33, 215.53] vs. 185.10 [160.30, 204.90], P = 0.051) and the number of metabolic syndrome components had a significant positive correlation with progranulin levels (r = 0.227, P = 0.010). In multiple regression analysis, IL-6 and triglyceride levels were significant predictors of serum progranulin levels (R-2 = 0.251). Furthermore, serum progranulin level was an independent predictor for increased CIMT in subjects without metabolic syndrome after adjusting for other cardiovascular risk factors (R-2 = 0.365). Conclusions: Serum progranulin levels are significantly associated with systemic inflammatory markers and were an independent predictor for atherosclerosis in subjects without metabolic syndrome. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | PUBLIC LIBRARY SCIENCE | - |
dc.subject | GROWTH-FACTOR | - |
dc.subject | ADIPOSE-TISSUE | - |
dc.subject | EPITHELIN PRECURSOR | - |
dc.subject | INSULIN-RESISTANCE | - |
dc.subject | SERUM PROGRANULIN | - |
dc.subject | ADIPOKINE | - |
dc.subject | DISEASE | - |
dc.subject | OBESITY | - |
dc.subject | ARTHRITIS | - |
dc.subject | GLUCOSE | - |
dc.title | Implication of Progranulin and C1q/TNF-Related Protein-3 (CTRP3) on Inflammation and Atherosclerosis in Subjects with or without Metabolic Syndrome | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Choi, Dong Seop | - |
dc.contributor.affiliatedAuthor | Baik, Sei Hyun | - |
dc.contributor.affiliatedAuthor | Choi, Kyung Mook | - |
dc.identifier.doi | 10.1371/journal.pone.0055744 | - |
dc.identifier.scopusid | 2-s2.0-84873597878 | - |
dc.identifier.wosid | 000315157200058 | - |
dc.identifier.bibliographicCitation | PLOS ONE, v.8, no.2 | - |
dc.relation.isPartOf | PLOS ONE | - |
dc.citation.title | PLOS ONE | - |
dc.citation.volume | 8 | - |
dc.citation.number | 2 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Science & Technology - Other Topics | - |
dc.relation.journalWebOfScienceCategory | Multidisciplinary Sciences | - |
dc.subject.keywordPlus | GROWTH-FACTOR | - |
dc.subject.keywordPlus | ADIPOSE-TISSUE | - |
dc.subject.keywordPlus | EPITHELIN PRECURSOR | - |
dc.subject.keywordPlus | INSULIN-RESISTANCE | - |
dc.subject.keywordPlus | SERUM PROGRANULIN | - |
dc.subject.keywordPlus | ADIPOKINE | - |
dc.subject.keywordPlus | DISEASE | - |
dc.subject.keywordPlus | OBESITY | - |
dc.subject.keywordPlus | ARTHRITIS | - |
dc.subject.keywordPlus | GLUCOSE | - |
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