tmc-1 encodes a sodium-sensitive channel required for salt chemosensation in C. elegans
DC Field | Value | Language |
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dc.contributor.author | Chatzigeorgiou, Marios | - |
dc.contributor.author | Bang, Sangsu | - |
dc.contributor.author | Hwang, Sun Wook | - |
dc.contributor.author | Schafer, William R. | - |
dc.date.accessioned | 2021-09-06T04:28:44Z | - |
dc.date.available | 2021-09-06T04:28:44Z | - |
dc.date.created | 2021-06-14 | - |
dc.date.issued | 2013-02-07 | - |
dc.identifier.issn | 0028-0836 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/103975 | - |
dc.description.abstract | Transmembrane channel-like (TMC) genes encode a broadly conserved family of multipass integral membrane proteins in animals(1,2). Human TMC1 and TMC2 genes are linked to human deafness and required for hair-cell mechanotransduction; however, the molecular functions of these and other TMC proteins have not been determined(3-6). Here we show that the Caenorhabditis elegans tmc-1 gene encodes a sodium sensor that functions specifically in salt taste chemosensation. tmc-1 is expressed in the ASH polymodal avoidance neurons, where it is required for salt-evoked neuronal activity and behavioural avoidance of high concentrations of NaCl. However, tmc-1 has no effect on responses to other stimuli sensed by the ASH neurons including high osmolarity and chemical repellents, indicating a specific role in salt sensation. When expressed in mammalian cell culture, C. elegans TMC-1 generates a predominantly cationic conductance activated by high extracellular sodium but not by other cations or uncharged small molecules. Thus, TMC-1 is both necessary for salt sensation in vivo and sufficient to generate a sodium-sensitive channel in vitro, identifying it as a probable ionotropic sensory receptor. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | NATURE PUBLISHING GROUP | - |
dc.subject | NUCLEOTIDE-GATED CHANNEL | - |
dc.subject | ASH NEURONS | - |
dc.subject | HEARING-LOSS | - |
dc.subject | GENE FAMILY | - |
dc.subject | HAIR-CELLS | - |
dc.subject | TASTE | - |
dc.subject | AVOIDANCE | - |
dc.subject | ADAPTATION | - |
dc.subject | BEHAVIORS | - |
dc.subject | MUTATIONS | - |
dc.title | tmc-1 encodes a sodium-sensitive channel required for salt chemosensation in C. elegans | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Hwang, Sun Wook | - |
dc.identifier.doi | 10.1038/nature11845 | - |
dc.identifier.scopusid | 2-s2.0-84874683479 | - |
dc.identifier.wosid | 000314741200041 | - |
dc.identifier.bibliographicCitation | NATURE, v.494, no.7435, pp.95 - 99 | - |
dc.relation.isPartOf | NATURE | - |
dc.citation.title | NATURE | - |
dc.citation.volume | 494 | - |
dc.citation.number | 7435 | - |
dc.citation.startPage | 95 | - |
dc.citation.endPage | 99 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Science & Technology - Other Topics | - |
dc.relation.journalWebOfScienceCategory | Multidisciplinary Sciences | - |
dc.subject.keywordPlus | NUCLEOTIDE-GATED CHANNEL | - |
dc.subject.keywordPlus | ASH NEURONS | - |
dc.subject.keywordPlus | HEARING-LOSS | - |
dc.subject.keywordPlus | GENE FAMILY | - |
dc.subject.keywordPlus | HAIR-CELLS | - |
dc.subject.keywordPlus | TASTE | - |
dc.subject.keywordPlus | AVOIDANCE | - |
dc.subject.keywordPlus | ADAPTATION | - |
dc.subject.keywordPlus | BEHAVIORS | - |
dc.subject.keywordPlus | MUTATIONS | - |
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