Calcium-sensing receptor and apoptosis in parathyroid hyperplasia of patients with secondary hyperparathyroidism
DC Field | Value | Language |
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dc.contributor.author | Lee, Hye-Jeong | - |
dc.contributor.author | Seo, U-Hyoung | - |
dc.contributor.author | Kim, Woo-Young | - |
dc.contributor.author | Woo, Sang-Uk | - |
dc.contributor.author | Lee, Jae-Bok | - |
dc.date.accessioned | 2021-09-06T04:35:06Z | - |
dc.date.available | 2021-09-06T04:35:06Z | - |
dc.date.created | 2021-06-14 | - |
dc.date.issued | 2013-02 | - |
dc.identifier.issn | 0300-0605 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/104012 | - |
dc.description.abstract | Objective: This retrospective study investigated the characteristics of secondary hyperparathyroidism (SHPT) by examining the presence of the calcium-sensing receptor (CaSR) and the rate of cell proliferation and apoptosis in parathyroid glands. Methods: Eighteen diffuse and 57 nodular hyperplastic parathyroid glands from 24 patients with SHPT were compared with 14 primary adenomas and 33 normal parathyroid glands using immunohistochemical staining of CaSR and a marker of proliferative activity (Ki67 antigen). Apoptosis was measured using the terminal deoxynucleotidyl transferase-mediated deoxyuridine triphosphate nick end labelling assay. Results: The mean +/- SE labelling index (LI) of CaSR (12.8% +/- 1.5%) in nodular hyperplasia was significantly lower than that in normal parathyroid glands (26.8% +/- 0.8%), whereas the mean +/- SE LI of CaSR in diffuse hyperplasia was similar to that in normal parathyroid glands (23.3% +/- 1.8%). The mean +/- SE LI of Ki67 antigen was significantly higher in primary adenoma and nodular hyperplasia than in normal parathyroid glands. Conclusion: These results indicate that downregulation of CaSR, and a higher rate of proliferation over apoptosis, could contribute to the pathological progression of SHPT. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | SAGE PUBLICATIONS LTD | - |
dc.subject | DOSE VITAMIN-D | - |
dc.subject | CINACALCET | - |
dc.subject | EXPRESSION | - |
dc.subject | PATHOGENESIS | - |
dc.subject | GLANDS | - |
dc.subject | CALCIFICATION | - |
dc.subject | HYPERCALCEMIA | - |
dc.subject | PROGRESSION | - |
dc.title | Calcium-sensing receptor and apoptosis in parathyroid hyperplasia of patients with secondary hyperparathyroidism | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Woo, Sang-Uk | - |
dc.contributor.affiliatedAuthor | Lee, Jae-Bok | - |
dc.identifier.doi | 10.1177/0300060513476600 | - |
dc.identifier.scopusid | 2-s2.0-84878393822 | - |
dc.identifier.wosid | 000319206500011 | - |
dc.identifier.bibliographicCitation | JOURNAL OF INTERNATIONAL MEDICAL RESEARCH, v.41, no.1, pp.97 - 105 | - |
dc.relation.isPartOf | JOURNAL OF INTERNATIONAL MEDICAL RESEARCH | - |
dc.citation.title | JOURNAL OF INTERNATIONAL MEDICAL RESEARCH | - |
dc.citation.volume | 41 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 97 | - |
dc.citation.endPage | 105 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Research & Experimental Medicine | - |
dc.relation.journalResearchArea | Pharmacology & Pharmacy | - |
dc.relation.journalWebOfScienceCategory | Medicine, Research & Experimental | - |
dc.relation.journalWebOfScienceCategory | Pharmacology & Pharmacy | - |
dc.subject.keywordPlus | DOSE VITAMIN-D | - |
dc.subject.keywordPlus | CINACALCET | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordPlus | PATHOGENESIS | - |
dc.subject.keywordPlus | GLANDS | - |
dc.subject.keywordPlus | CALCIFICATION | - |
dc.subject.keywordPlus | HYPERCALCEMIA | - |
dc.subject.keywordPlus | PROGRESSION | - |
dc.subject.keywordAuthor | Calcium-sensing receptor | - |
dc.subject.keywordAuthor | chronic kidney disease | - |
dc.subject.keywordAuthor | parathyroid gland | - |
dc.subject.keywordAuthor | parathyroid hormone | - |
dc.subject.keywordAuthor | secondary hyperparathyroidism | - |
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