Infectious complications following allogeneic stem cell transplantation: reduced-intensity vs. myeloablative conditioning regimens
- Authors
- Kim, S. -H.; Kee, S. Y.; Lee, D. -G.; Choi, S. -M.; Park, S. H.; Kwon, J. -C.; Eom, K. -S.; Kim, Y. -J.; Kim, H. -J.; Lee, S.; Min, C. -K.; Kim, D. -W.; Choi, J. -H.; Yoo, J. -H.; Lee, J. -W.; Min, W. -S.
- Issue Date
- 2월-2013
- Publisher
- WILEY
- Keywords
- infection; allogeneic stem cell transplantation; transplantation conditioning; mortality
- Citation
- TRANSPLANT INFECTIOUS DISEASE, v.15, no.1, pp.49 - 59
- Indexed
- SCIE
SCOPUS
- Journal Title
- TRANSPLANT INFECTIOUS DISEASE
- Volume
- 15
- Number
- 1
- Start Page
- 49
- End Page
- 59
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/104014
- DOI
- 10.1111/tid.12003
- ISSN
- 1398-2273
- Abstract
- Background. In allogeneic stem cell transplantation (allo-SCT), reduced-intensity conditioning (RIC) is known for producing less regimen-related toxicity. However, whether or not RIC reduces the risk for infection and infection-related mortality (IRM) remains controversial. Methods. We retrospectively analyzed infectious episodes and IRMs after allo-SCTs by time period and by the intensity of the conditioning regimen (RIC [n = 81] vs. myeloablative conditioning, MAC [n = 150]). Results. The cumulative incidence of any kind of infection was lower in the RIC group through the entire period (72% vs. 87%; P = 0.007). The onset of infections was deferred in the RIC group as compared with the MAC group (P = 0.012). Bacteremia occurred less frequently in the RIC group through the entire period (5% vs. 14%; P = 0.044). However, the incidences of cytomegalovirus reactivation and disease, herpes zoster, virus-associated hemorrhagic cystitis, and invasive fungal infection were not different between the two groups. Furthermore, there was no difference in relapse-free survival and IRM between the two conditioning regimens. Conclusion. Careful monitoring and appropriate preventive/therapeutic strategies for infectious complications, comparable to those for allo-SCT recipients with MAC, should also be applied to those with RIC, especially after engraftment.
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Collections - College of Medicine > Department of Medical Science > 1. Journal Articles
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