Can Serum be Used for Analyzing the EGFR Mutation Status in Patients with Advanced Non-small Cell Lung Cancer?
DC Field | Value | Language |
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dc.contributor.author | Kim, Seung Tae | - |
dc.contributor.author | Jung, Hae-Yun | - |
dc.contributor.author | Sung, Jae Sook | - |
dc.contributor.author | Jo, Uk Hyun | - |
dc.contributor.author | Tanaka, Tomoaki | - |
dc.contributor.author | Hagiwara, Koichi | - |
dc.contributor.author | Park, Kyong Hwa | - |
dc.contributor.author | Shin, Sang Won | - |
dc.contributor.author | Kim, Jun Suk | - |
dc.contributor.author | Kim, Yeul Hong | - |
dc.date.accessioned | 2021-09-06T04:37:45Z | - |
dc.date.available | 2021-09-06T04:37:45Z | - |
dc.date.created | 2021-06-14 | - |
dc.date.issued | 2013-02 | - |
dc.identifier.issn | 0277-3732 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/104027 | - |
dc.description.abstract | Background: Epidermal growth factor receptor (EGFR) mutations as prognostic or predictive marker in patients with non-small cell lung cancer (NSCLC) have been used widely. However, it may be difficult to get tumor tissue for analyzing the status of EGFR mutation status in large proportion of patients with advanced disease. Patients and Methods: We obtained pairs of tumor and serum samples from 57 patients with advanced NSCLC, between March 2006 and January 2009. EGFR mutation status from tumor samples was analyzed by genomic polymerase chain reaction and direct sequence and EGFR mutation status from serum samples was determined by the peptide nucleic acid locked nucleic acid polymerase chain reaction clamp. Results: EGFR mutations were detected in the serum samples of 11 patients and in the tumor samples of 12 patients. EGFR mutation status in the serum and tumor samples was consistent in 50 of the 57 pairs (87.7%). There was a high correlation between the mutations detected in serum sample and the mutations detected in the matched tumor sample (correlation index 0.62; P < 0.001). Twenty-two of 57 patients (38.5%) received EGFR-tyrosine kinase inhibitors as any line therapy. The response for EGFR- tyrosine kinase inhibitors was significantly associated with EGFR mutations in both tumor samples and serum samples (P < 0.05). There was no significant differences in overall survival according to the status of EGFR mutations in both serum and tumor samples (P > 0.05). Conclusions: Serum sample might be alternatively used in the difficult time of getting tumor tissue for analyzing the status of EGFR mutation status in patients with advanced NSCLC. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | LIPPINCOTT WILLIAMS & WILKINS | - |
dc.subject | GROWTH-FACTOR-RECEPTOR | - |
dc.subject | GENE AMPLIFICATION | - |
dc.subject | TYROSINE KINASE | - |
dc.subject | GEFITINIB | - |
dc.subject | CHEMOTHERAPY | - |
dc.subject | DNA | - |
dc.subject | ADENOCARCINOMA | - |
dc.subject | ERLOTINIB | - |
dc.subject | TRIALS | - |
dc.subject | CLAMP | - |
dc.title | Can Serum be Used for Analyzing the EGFR Mutation Status in Patients with Advanced Non-small Cell Lung Cancer? | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Kim, Seung Tae | - |
dc.contributor.affiliatedAuthor | Park, Kyong Hwa | - |
dc.contributor.affiliatedAuthor | Shin, Sang Won | - |
dc.contributor.affiliatedAuthor | Kim, Jun Suk | - |
dc.contributor.affiliatedAuthor | Kim, Yeul Hong | - |
dc.identifier.doi | 10.1097/COC.0b013e31823a5217 | - |
dc.identifier.scopusid | 2-s2.0-84872913887 | - |
dc.identifier.wosid | 000313795200011 | - |
dc.identifier.bibliographicCitation | AMERICAN JOURNAL OF CLINICAL ONCOLOGY-CANCER CLINICAL TRIALS, v.36, no.1, pp.57 - 63 | - |
dc.relation.isPartOf | AMERICAN JOURNAL OF CLINICAL ONCOLOGY-CANCER CLINICAL TRIALS | - |
dc.citation.title | AMERICAN JOURNAL OF CLINICAL ONCOLOGY-CANCER CLINICAL TRIALS | - |
dc.citation.volume | 36 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 57 | - |
dc.citation.endPage | 63 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Oncology | - |
dc.relation.journalWebOfScienceCategory | Oncology | - |
dc.subject.keywordPlus | GROWTH-FACTOR-RECEPTOR | - |
dc.subject.keywordPlus | GENE AMPLIFICATION | - |
dc.subject.keywordPlus | TYROSINE KINASE | - |
dc.subject.keywordPlus | GEFITINIB | - |
dc.subject.keywordPlus | CHEMOTHERAPY | - |
dc.subject.keywordPlus | DNA | - |
dc.subject.keywordPlus | ADENOCARCINOMA | - |
dc.subject.keywordPlus | ERLOTINIB | - |
dc.subject.keywordPlus | TRIALS | - |
dc.subject.keywordPlus | CLAMP | - |
dc.subject.keywordAuthor | EGFR mutation | - |
dc.subject.keywordAuthor | serum and tumor samples | - |
dc.subject.keywordAuthor | NSCLC | - |
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