IK Induced by Coxsackievirus B3 Infection Transiently Downregulates Expression of MHC Class II Through Increasing cAMP
DC Field | Value | Language |
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dc.contributor.author | Park, Hye-Lim | - |
dc.contributor.author | Kim, Yeon-Jung | - |
dc.contributor.author | Na, Ha-Na | - |
dc.contributor.author | Park, Mi-Young | - |
dc.contributor.author | Kim, Joo-Young | - |
dc.contributor.author | Yun, Cheol-Won | - |
dc.contributor.author | Nam, Jae-Hwan | - |
dc.date.accessioned | 2021-09-06T04:42:01Z | - |
dc.date.available | 2021-09-06T04:42:01Z | - |
dc.date.created | 2021-06-14 | - |
dc.date.issued | 2013-02 | - |
dc.identifier.issn | 0882-8245 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/104052 | - |
dc.description.abstract | Major histocompatibility complex (MHC) class II expression is critical for the presentation of antigens in the immune response to viral infection. Consequently, some viruses regulate the MHC class II-mediated presentation of viral antigens as a mechanism of immune escape. In this study, we found that Coxsackievirus B3 (CVB3) infection transiently increased IK expression, which reduced the expression of MHC class II (I-A/I-E) on splenic B cells. Interestingly, CVB3-induced IK elevated cAMP, a downstream molecule of the G protein-coupled receptors, which inhibited MHC class II presentation on B cells. Transgenic mice expressing truncated IK showed lower expression of MHC class II on B cells than did wild-type mice after CVB3 infection. Taken together, these results imply that IK plays a role in downregulating MHC class II expression on B cells during CVB3 infection through the induction of cAMP. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | MARY ANN LIEBERT, INC | - |
dc.subject | IFN-GAMMA | - |
dc.subject | BORDETELLA-PERTUSSIS | - |
dc.subject | ANTIBODY-RESPONSES | - |
dc.subject | DENDRITIC CELLS | - |
dc.subject | ANTIGEN-PRESENTATION | - |
dc.subject | INNATE IMMUNITY | - |
dc.subject | CYCLIC-AMP | - |
dc.subject | T-CELLS | - |
dc.subject | TRANSACTIVATOR | - |
dc.subject | MYOCARDITIS | - |
dc.title | IK Induced by Coxsackievirus B3 Infection Transiently Downregulates Expression of MHC Class II Through Increasing cAMP | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Yun, Cheol-Won | - |
dc.identifier.doi | 10.1089/vim.2012.0054 | - |
dc.identifier.scopusid | 2-s2.0-84874093421 | - |
dc.identifier.wosid | 000315098200003 | - |
dc.identifier.bibliographicCitation | VIRAL IMMUNOLOGY, v.26, no.1, pp.13 - 24 | - |
dc.relation.isPartOf | VIRAL IMMUNOLOGY | - |
dc.citation.title | VIRAL IMMUNOLOGY | - |
dc.citation.volume | 26 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 13 | - |
dc.citation.endPage | 24 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Immunology | - |
dc.relation.journalResearchArea | Virology | - |
dc.relation.journalWebOfScienceCategory | Immunology | - |
dc.relation.journalWebOfScienceCategory | Virology | - |
dc.subject.keywordPlus | IFN-GAMMA | - |
dc.subject.keywordPlus | BORDETELLA-PERTUSSIS | - |
dc.subject.keywordPlus | ANTIBODY-RESPONSES | - |
dc.subject.keywordPlus | DENDRITIC CELLS | - |
dc.subject.keywordPlus | ANTIGEN-PRESENTATION | - |
dc.subject.keywordPlus | INNATE IMMUNITY | - |
dc.subject.keywordPlus | CYCLIC-AMP | - |
dc.subject.keywordPlus | T-CELLS | - |
dc.subject.keywordPlus | TRANSACTIVATOR | - |
dc.subject.keywordPlus | MYOCARDITIS | - |
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