Folate-modified-chitosan-coated liposomes for tumor-targeted drug delivery
- Authors
- Yang, Kui Kun; Kong, Ming; Wei, Ya Nan; Liu, Ya; Cheng, Xiao Jie; Li, Jing; Park, Hyun Jin; Chen, Xi Guang
- Issue Date
- 2월-2013
- Publisher
- SPRINGER
- Citation
- JOURNAL OF MATERIALS SCIENCE, v.48, no.4, pp.1717 - 1728
- Indexed
- SCIE
SCOPUS
- Journal Title
- JOURNAL OF MATERIALS SCIENCE
- Volume
- 48
- Number
- 4
- Start Page
- 1717
- End Page
- 1728
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/104106
- DOI
- 10.1007/s10853-012-6930-0
- ISSN
- 0022-2461
- Abstract
- In this study, a folate-modified-chitosan-coated liposome (FCCL) was prepared for tumor-targeted drug delivery. The folate-chitosan conjugates were characterized using H-1 NMR and infrared spectrum analysis. The properties of folate-chitosan-coated liposomes (FCCLs) were studied and compared with those of traditional liposomes and chitosan-coated liposomes (CCLs). FCCLs were spherical in shape with a classic core-shell structure. Compared with conventional liposomes, FCCLs had larger size (average diameter: 182.0 nm), higher zeta potential (10.1 mV), prolonged drug release behaviors (55.76 % after 24 h), and better physical stability when stored at 25 degrees C, all similar to the properties of CCLs. With fluorescein as a model drug, fluorescein-loaded liposomes, CCLs, and FCCLs were prepared and their tumor targeting ability was evaluated according to the in vitro cellular uptake of fluorescein loaded nanoparticles by MCF-7 and HUVEC cells. Results demonstrated that FCCLs had a significant higher uptake by folate receptor positive cells (MCF-7) as compared to traditional liposomes and CCLs, which indicated that the FCCLs were promising nano-carriers for tumor-targeted drug delivery.
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Collections - Graduate School > Department of Biotechnology > 1. Journal Articles
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