When a ribosome encounters a premature termination codon
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Hwang, Jungwook | - |
dc.contributor.author | Kim, Yoon Ki | - |
dc.date.accessioned | 2021-09-06T04:59:34Z | - |
dc.date.available | 2021-09-06T04:59:34Z | - |
dc.date.created | 2021-06-14 | - |
dc.date.issued | 2013-01-31 | - |
dc.identifier.issn | 1976-6696 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/104163 | - |
dc.description.abstract | In mammalian cells, aberrant transcripts harboring a premature termination codon (PTC) can be generated by abnormal or inefficient biogenesis of mRNAs or by somatic mutation. Truncated polypeptides synthesized from these aberrant transcripts could be toxic to normal cellular functions. However, mammalian cells have evolved sophisticated mechanisms for monitoring the quality of mRNAs. The faulty transcripts harboring PTC are subject to nonsense-mediated mRNA decay (NMD), nonsense-mediated translational repression (NMTR), nonsense-associated alternative splicing (NAS), or nonsense-mediated transcriptional gene silencing (NMTGS). In this review, we briefly outline the molecular characteristics of each pathway and suggest mRNA quality control mechanisms as a means to regulate normal gene expression. [BMB Reports 2013; 46(1): 9-16] | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | KOREAN SOCIETY BIOCHEMISTRY & MOLECULAR BIOLOGY | - |
dc.subject | MESSENGER-RNA DECAY | - |
dc.subject | NONSENSE-MEDIATED DECAY | - |
dc.subject | EXON-JUNCTION COMPLEX | - |
dc.subject | CBP80/20-DEPENDENT TRANSLATION | - |
dc.subject | MAMMALIAN-CELLS | - |
dc.subject | QUALITY-CONTROL | - |
dc.subject | READING FRAME | - |
dc.subject | SURVEILLANCE | - |
dc.subject | DEGRADATION | - |
dc.subject | PATHWAY | - |
dc.title | When a ribosome encounters a premature termination codon | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Kim, Yoon Ki | - |
dc.identifier.doi | 10.5483/BMBRep.2013.46.1.002 | - |
dc.identifier.wosid | 000317959700002 | - |
dc.identifier.bibliographicCitation | BMB REPORTS, v.46, no.1, pp.9 - 16 | - |
dc.relation.isPartOf | BMB REPORTS | - |
dc.citation.title | BMB REPORTS | - |
dc.citation.volume | 46 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 9 | - |
dc.citation.endPage | 16 | - |
dc.type.rims | ART | - |
dc.type.docType | Review | - |
dc.identifier.kciid | ART001738674 | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.subject.keywordPlus | MESSENGER-RNA DECAY | - |
dc.subject.keywordPlus | NONSENSE-MEDIATED DECAY | - |
dc.subject.keywordPlus | EXON-JUNCTION COMPLEX | - |
dc.subject.keywordPlus | CBP80/20-DEPENDENT TRANSLATION | - |
dc.subject.keywordPlus | MAMMALIAN-CELLS | - |
dc.subject.keywordPlus | QUALITY-CONTROL | - |
dc.subject.keywordPlus | READING FRAME | - |
dc.subject.keywordPlus | SURVEILLANCE | - |
dc.subject.keywordPlus | DEGRADATION | - |
dc.subject.keywordPlus | PATHWAY | - |
dc.subject.keywordAuthor | NAS | - |
dc.subject.keywordAuthor | NMD | - |
dc.subject.keywordAuthor | NMTGS | - |
dc.subject.keywordAuthor | NMTR | - |
dc.subject.keywordAuthor | PTC | - |
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