Impaired mobilization of bone marrow derived CD34 positive mononuclear cells is related to the recurrence of atrial fibrillation after radiofrequency catheter ablation
DC Field | Value | Language |
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dc.contributor.author | Shim, Jaemin | - |
dc.contributor.author | Park, Jae Hyung | - |
dc.contributor.author | Kim, Jong Youn | - |
dc.contributor.author | Kim, Sook Kyoung | - |
dc.contributor.author | Joung, Boyoung | - |
dc.contributor.author | Lee, Moon-Hyoung | - |
dc.contributor.author | Kim, Young-Hoon | - |
dc.contributor.author | Pak, Hui-Nam | - |
dc.date.accessioned | 2021-09-06T05:12:49Z | - |
dc.date.available | 2021-09-06T05:12:49Z | - |
dc.date.created | 2021-06-14 | - |
dc.date.issued | 2013-01-20 | - |
dc.identifier.issn | 0167-5273 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/104181 | - |
dc.description.abstract | Background: We have reported previously that non-ischemic titrated cardiac injury by radiofrequency catheter ablation (RFCA) of atrial fibrillation (AF) mobilizes bone marrow derived CD34+ mononuclear cells. We hypothesized that the degree of post-RFCA CD34+ cell mobilization affects the clinical outcome of AF ablation. Methods and Results: Fifty-six patients (39 males, 53 +/- 13 years) who underwent electrophysiology study (EPS; n=10) or RFCA of AF (n=46) were included. The peripheral blood CD34+ cell count and multiple serologic markers were evaluated before, immediately after the procedure. Results: 1. The percent increase of CD34+ cells (%Delta CD34+) was significant after RFCA as compared to EPS (p<0.01). 2. The post-RFCA CD34+ cell count was significantly higher in patients who underwent RF energy delivery >= 80 min than those <80 min (p=0.024). 3. The %Delta CD34+ was linearly correlated with the plasma level of troponin I (R=0.38, p<0.01), but not with the non-ablation procedure time (p=NS). 3. During 30.2 +/- 2.7 months follow-up, AF recurred in 37% of patients including early recurrence (34.8%). In contrast, the patients in whom AF recurred received a longer duration of RF energy delivery than those remaining in sinus rhythm (p=0.04), they were associated with lower %Delta CD34+ (p=0.02). Conclusion: CD34+ mononuclear cells were mobilized after catheter ablation by RF energy dose dependent manner, and the duration of RF energy delivery was longer in patients with AF recurrence. However, CD34+ mononuclear cell mobilization was significantly impaired in patients with recurring AF after RFCA. (C) 2011 Elsevier Ireland Ltd. All rights reserved. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | ELSEVIER IRELAND LTD | - |
dc.subject | ENDOTHELIAL PROGENITOR CELLS | - |
dc.subject | HEMATOPOIETIC STEM | - |
dc.title | Impaired mobilization of bone marrow derived CD34 positive mononuclear cells is related to the recurrence of atrial fibrillation after radiofrequency catheter ablation | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Shim, Jaemin | - |
dc.contributor.affiliatedAuthor | Kim, Young-Hoon | - |
dc.identifier.doi | 10.1016/j.ijcard.2011.05.064 | - |
dc.identifier.scopusid | 2-s2.0-84872486802 | - |
dc.identifier.wosid | 000313746300018 | - |
dc.identifier.bibliographicCitation | INTERNATIONAL JOURNAL OF CARDIOLOGY, v.162, no.3, pp.179 - 183 | - |
dc.relation.isPartOf | INTERNATIONAL JOURNAL OF CARDIOLOGY | - |
dc.citation.title | INTERNATIONAL JOURNAL OF CARDIOLOGY | - |
dc.citation.volume | 162 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 179 | - |
dc.citation.endPage | 183 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Cardiovascular System & Cardiology | - |
dc.relation.journalWebOfScienceCategory | Cardiac & Cardiovascular Systems | - |
dc.subject.keywordPlus | ENDOTHELIAL PROGENITOR CELLS | - |
dc.subject.keywordPlus | HEMATOPOIETIC STEM | - |
dc.subject.keywordAuthor | CD34+mononuclear cell | - |
dc.subject.keywordAuthor | Atrial fibrillation | - |
dc.subject.keywordAuthor | Catheter ablation | - |
dc.subject.keywordAuthor | Recurrence | - |
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