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The ribonuclease L-dependent antiviral roles of human 2 ',5 '-oligoadenylate synthetase family members against hepatitis C virus

Authors
Kwon, Young-ChanKang, Ju-IlHwang, Soon B.Ahn, Byung-Yoon
Issue Date
16-1월-2013
Publisher
ELSEVIER SCIENCE BV
Keywords
RNase L, 2 ' ,5 ' -Oligoadenylate synthetase; Hepatitis C virus; Antiviral protein
Citation
FEBS LETTERS, v.587, no.2, pp.156 - 164
Indexed
SCIE
SCOPUS
Journal Title
FEBS LETTERS
Volume
587
Number
2
Start Page
156
End Page
164
URI
https://scholar.korea.ac.kr/handle/2021.sw.korea/104187
DOI
10.1016/j.febslet.2012.11.010
ISSN
0014-5793
Abstract
The latent ribonuclease RNase L and the interferon-inducible 2',5'-oligoadenylate synthetase (OAS) have been implicated in the antiviral response against hepatitis C virus (HCV). However, the specific roles of these enzymes against HCV have not been fully elucidated. In this study, a scarce endogenous expression and RNA degrading activity of RNase L in human hepatoma Huh7 cells enabled us to demonstrate the antiviral activity of RNase L against HCV replication through the transient expression of the enzyme. The antiviral potential of specific members of the OAS family was further examined through overexpression and RNA interference approaches. Our data suggested that among the members of the OAS family, OAS1 p46 and OAS3 p100 mediate the RNase L-dependent antiviral activity against HCV. (C) 2012 Federation of European Biochemical Societies. Published by Elsevier B. V. All rights reserved.
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