Interleukin-10 Promoter Gene Polymorphisms and Susceptibility to Asthma: A Meta-Analysis
DC Field | Value | Language |
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dc.contributor.author | Hyun, Myung-Han | - |
dc.contributor.author | Lee, Chung-Ho | - |
dc.contributor.author | Kang, Min-Hyung | - |
dc.contributor.author | Park, Bong-Kyung | - |
dc.contributor.author | Lee, Young Ho | - |
dc.date.accessioned | 2021-09-06T05:15:23Z | - |
dc.date.available | 2021-09-06T05:15:23Z | - |
dc.date.created | 2021-06-14 | - |
dc.date.issued | 2013-01-15 | - |
dc.identifier.issn | 1932-6203 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/104197 | - |
dc.description.abstract | Objective: The aim of this study was to explore whether the interleukin (IL)-10 polymorphisms and their haplotypes contribute to asthma susceptibility. Methods: MEDLINE, EMBASE and the COCHRANE library databases were utilized to identify available articles. A meta-analysis was conducted on IL-10 -1082 G/A, -819 C/T, -592 C/A polymorphisms, and their haplotypes and asthma. Results: Eleven studies involving 2,215 asthma patients and 2,170 controls were considered in the meta-analysis. The meta-analysis revealed no association between asthma and the IL-10 -1082 G allele [Odds ratio (OR) = 0.87, 95% Confidence interval (CI) = 0.68-1.12, p = 0.28]. However, meta-analysis of the five studies in Hardy-Weinburg equilibrium produced the relationship between the IL-10 -1082 G allele and asthma (OR = 0.71, 95% CI = 0.60-0.83, p, 0.0001). Stratification by ethnicity indicated an association between the IL-10 -1082 G allele and asthma in East Asians (OR = 0.74, 95% CI = 0.57-0.96, p = 0.02), but not in West Asians. Furthermore, stratification by age indicated an association between the IL-10 -1082 G allele and asthma in adults and mixed groups (OR = 0.77, 95% CI = 0.62-0.96, p = 0.02; OR = 0.67, 95% CI = 0.49-0.92, p = 0.01). No association was found between asthma and IL-10 -819 C/T and IL-10 -592 C/A polymorphisms and their haplotypes. Conclusion: The IL-10 -1082 G/A polymorphism confers susceptibility to asthma in East Asians and in adults. However, the IL-10 -819 C/T, -592 C/A polymorphisms and their haplotypes are not associated with asthma. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | PUBLIC LIBRARY SCIENCE | - |
dc.subject | SYSTEMIC-LUPUS-ERYTHEMATOSUS | - |
dc.subject | RHEUMATOID-ARTHRITIS | - |
dc.subject | ASSOCIATION | - |
dc.subject | IL-10 | - |
dc.subject | RECEPTOR | - |
dc.subject | INFLAMMATION | - |
dc.subject | CHILDREN | - |
dc.subject | DISEASE | - |
dc.subject | REGION | - |
dc.subject | SENSITIZATION | - |
dc.title | Interleukin-10 Promoter Gene Polymorphisms and Susceptibility to Asthma: A Meta-Analysis | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Lee, Young Ho | - |
dc.identifier.doi | 10.1371/journal.pone.0053758 | - |
dc.identifier.scopusid | 2-s2.0-84872367318 | - |
dc.identifier.wosid | 000314707700030 | - |
dc.identifier.bibliographicCitation | PLOS ONE, v.8, no.1 | - |
dc.relation.isPartOf | PLOS ONE | - |
dc.citation.title | PLOS ONE | - |
dc.citation.volume | 8 | - |
dc.citation.number | 1 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Science & Technology - Other Topics | - |
dc.relation.journalWebOfScienceCategory | Multidisciplinary Sciences | - |
dc.subject.keywordPlus | SYSTEMIC-LUPUS-ERYTHEMATOSUS | - |
dc.subject.keywordPlus | RHEUMATOID-ARTHRITIS | - |
dc.subject.keywordPlus | ASSOCIATION | - |
dc.subject.keywordPlus | IL-10 | - |
dc.subject.keywordPlus | RECEPTOR | - |
dc.subject.keywordPlus | INFLAMMATION | - |
dc.subject.keywordPlus | CHILDREN | - |
dc.subject.keywordPlus | DISEASE | - |
dc.subject.keywordPlus | REGION | - |
dc.subject.keywordPlus | SENSITIZATION | - |
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