Comparative Study of Helicobacter pylori Eradication Rates With 5-day Quadruple "Concomitant" Therapy and 7-day Standard Triple Therapy
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kim, Seung Young | - |
dc.contributor.author | Lee, Sang Woo | - |
dc.contributor.author | Hyun, Jong Jin | - |
dc.contributor.author | Jung, Sung Woo | - |
dc.contributor.author | Koo, Ja Seol | - |
dc.contributor.author | Yim, Hyung Joon | - |
dc.contributor.author | Park, Jong Jae | - |
dc.contributor.author | Chun, Hoon Jai | - |
dc.contributor.author | Choi, Jai Hyun | - |
dc.date.accessioned | 2021-09-06T05:35:09Z | - |
dc.date.available | 2021-09-06T05:35:09Z | - |
dc.date.created | 2021-06-14 | - |
dc.date.issued | 2013-01 | - |
dc.identifier.issn | 0192-0790 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/104272 | - |
dc.description.abstract | Background: Several studies have shown the superiority of concomitant quadruple therapy containing 3 antibiotics over triple therapy for Helicobacter pylori infection. The aim of this study was to compare concomitant quadruple therapy with standard triple therapy for first-line H. pylori eradication. Methods: A total of 270 patients with proven H. pylori infection were randomly assigned to one of 2 regimens: amoxicillin 1000mg with clarithromycin 500mg and lansoprazole 30mg twice daily for 7 days (triple therapy) or amoxicillin 1000mg with clarithromycin 500mg, metronidazole 500mg, and lansoprazole 30mg twice daily for 5 days (concomitant therapy). The success of eradication was evaluated 4 to 5 weeks after completion of treatment. Results: Eradication rates were 86.1% in the triple therapy and 91.4% in the concomitant therapy (per protocol), but the difference was not statistically significant. Mild adverse events were more frequently reported in the concomitant-therapy group (35.6%) than in the triple-therapy group (25.2%) (P=0.09). Conclusions: Five-day quadruple concomitant therapy eradicated H. pylori in over 90% of patients. Accordingly, concomitant therapy is thought to be a promising alternative to triple therapy as a first-line treatment regimen for H. pylori eradication. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | LIPPINCOTT WILLIAMS & WILKINS | - |
dc.subject | ANTIBIOTIC-RESISTANCE | - |
dc.subject | SEQUENTIAL THERAPY | - |
dc.subject | CLARITHROMYCIN | - |
dc.subject | INFECTION | - |
dc.subject | LANSOPRAZOLE | - |
dc.subject | METAANALYSIS | - |
dc.subject | AMOXICILLIN | - |
dc.subject | REGIMEN | - |
dc.subject | 4-DRUG | - |
dc.title | Comparative Study of Helicobacter pylori Eradication Rates With 5-day Quadruple "Concomitant" Therapy and 7-day Standard Triple Therapy | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Kim, Seung Young | - |
dc.contributor.affiliatedAuthor | Lee, Sang Woo | - |
dc.contributor.affiliatedAuthor | Hyun, Jong Jin | - |
dc.contributor.affiliatedAuthor | Jung, Sung Woo | - |
dc.contributor.affiliatedAuthor | Koo, Ja Seol | - |
dc.contributor.affiliatedAuthor | Yim, Hyung Joon | - |
dc.contributor.affiliatedAuthor | Park, Jong Jae | - |
dc.contributor.affiliatedAuthor | Chun, Hoon Jai | - |
dc.contributor.affiliatedAuthor | Choi, Jai Hyun | - |
dc.identifier.doi | 10.1097/MCG.0b013e3182548ad4 | - |
dc.identifier.scopusid | 2-s2.0-84871607030 | - |
dc.identifier.wosid | 000313106000007 | - |
dc.identifier.bibliographicCitation | JOURNAL OF CLINICAL GASTROENTEROLOGY, v.47, no.1, pp.21 - 24 | - |
dc.relation.isPartOf | JOURNAL OF CLINICAL GASTROENTEROLOGY | - |
dc.citation.title | JOURNAL OF CLINICAL GASTROENTEROLOGY | - |
dc.citation.volume | 47 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 21 | - |
dc.citation.endPage | 24 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Gastroenterology & Hepatology | - |
dc.relation.journalWebOfScienceCategory | Gastroenterology & Hepatology | - |
dc.subject.keywordPlus | ANTIBIOTIC-RESISTANCE | - |
dc.subject.keywordPlus | SEQUENTIAL THERAPY | - |
dc.subject.keywordPlus | CLARITHROMYCIN | - |
dc.subject.keywordPlus | INFECTION | - |
dc.subject.keywordPlus | LANSOPRAZOLE | - |
dc.subject.keywordPlus | METAANALYSIS | - |
dc.subject.keywordPlus | AMOXICILLIN | - |
dc.subject.keywordPlus | REGIMEN | - |
dc.subject.keywordPlus | 4-DRUG | - |
dc.subject.keywordAuthor | Helicobacter pylori | - |
dc.subject.keywordAuthor | drug therapy | - |
dc.subject.keywordAuthor | combination | - |
dc.subject.keywordAuthor | concomitant therapy | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
(02841) 서울특별시 성북구 안암로 14502-3290-1114
COPYRIGHT © 2021 Korea University. All Rights Reserved.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.