Pre-clinical evaluation of the infant Jarvik 2000 heart in a neonate piglet model
DC Field | Value | Language |
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dc.contributor.author | Wei, Xufeng | - |
dc.contributor.author | Li, Tieluo | - |
dc.contributor.author | Li, Shuying | - |
dc.contributor.author | Son, Ho Sung | - |
dc.contributor.author | Sanchez, Pablo | - |
dc.contributor.author | Niu, Shuqiong | - |
dc.contributor.author | Watkins, A. Claire | - |
dc.contributor.author | DeFilippi, Christopher | - |
dc.contributor.author | Jarvik, Robert | - |
dc.contributor.author | Wu, Zhongjun J. | - |
dc.contributor.author | Griffith, Bartley P. | - |
dc.date.accessioned | 2021-09-06T05:45:00Z | - |
dc.date.available | 2021-09-06T05:45:00Z | - |
dc.date.created | 2021-06-14 | - |
dc.date.issued | 2013-01 | - |
dc.identifier.issn | 1053-2498 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/104330 | - |
dc.description.abstract | BACKGROUND: The infant Jarvik 2000 heart is a very small, hermetically sealed, intracorporeal, axial-flow ventricular assist device (VAD) designed for circulatory support in neonates and infants. The anatomic fit, short-term biocompatibility and hemodynamic performance of the device were evaluated in a neonate piglet model. METHODS: The infant Jarvik 2000 heart with two different blade profiles (low- or high-flow blade design) was tested in 6 piglets (8.8 +/- 0.9 kg). Using a median sternotomy, the pump was placed in the left ventricle through the apex without cardiopulmonary bypass. An outflow graft was anastomosed to the ascending aorta. Hemodynamics and biocompatibility were studied for 6 hours. RESULTS: All 6 pumps were implanted without complication. Optimal anatomic positioning was found with the pump body inserted 2.4 cm into the left ventricle. Hemodynamics demonstrated stability throughout the 6-hour duration. The pump flow increased from 0.27 to 0.95 liter/min at increasing speeds from 18 to 31 krpm for the low-flow blade design, whereas the pump flow increased from 0.54 liter/min to 1.12 liters/min at increasing speeds from 16 krpm to 31 krpm for the high-flow blade design. At higher speeds, >80% of flow could be supplied by the device. Blood chemistry and final pathology demonstrated no acute organ injury or thrombosis for either blade design. CONCLUSIONS: The infant Jarvik 2000 heart is anatomically and biologically compatible with an short-term neonate piglet model. This in vivo study demonstrates the future feasibility of this device for clinical use. J Heart Lung Transplant 2013;32:112-119 (C) 2013 International Society for Heart and Lung Transplantation. All rights reserved. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | ELSEVIER SCIENCE INC | - |
dc.subject | VENTRICULAR ASSIST DEVICE | - |
dc.subject | MECHANICAL CIRCULATORY SUPPORT | - |
dc.subject | NATIONAL HEART | - |
dc.subject | UNITED-STATES | - |
dc.subject | EXPERIENCE | - |
dc.subject | CHILDREN | - |
dc.subject | TRANSPLANTATION | - |
dc.subject | LUNG | - |
dc.subject | PROGRAM | - |
dc.title | Pre-clinical evaluation of the infant Jarvik 2000 heart in a neonate piglet model | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Son, Ho Sung | - |
dc.identifier.doi | 10.1016/j.healun.2012.10.011 | - |
dc.identifier.scopusid | 2-s2.0-84871382838 | - |
dc.identifier.wosid | 000313223000018 | - |
dc.identifier.bibliographicCitation | JOURNAL OF HEART AND LUNG TRANSPLANTATION, v.32, no.1, pp.112 - 119 | - |
dc.relation.isPartOf | JOURNAL OF HEART AND LUNG TRANSPLANTATION | - |
dc.citation.title | JOURNAL OF HEART AND LUNG TRANSPLANTATION | - |
dc.citation.volume | 32 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 112 | - |
dc.citation.endPage | 119 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Cardiovascular System & Cardiology | - |
dc.relation.journalResearchArea | Respiratory System | - |
dc.relation.journalResearchArea | Surgery | - |
dc.relation.journalResearchArea | Transplantation | - |
dc.relation.journalWebOfScienceCategory | Cardiac & Cardiovascular Systems | - |
dc.relation.journalWebOfScienceCategory | Respiratory System | - |
dc.relation.journalWebOfScienceCategory | Surgery | - |
dc.relation.journalWebOfScienceCategory | Transplantation | - |
dc.subject.keywordPlus | VENTRICULAR ASSIST DEVICE | - |
dc.subject.keywordPlus | MECHANICAL CIRCULATORY SUPPORT | - |
dc.subject.keywordPlus | NATIONAL HEART | - |
dc.subject.keywordPlus | UNITED-STATES | - |
dc.subject.keywordPlus | EXPERIENCE | - |
dc.subject.keywordPlus | CHILDREN | - |
dc.subject.keywordPlus | TRANSPLANTATION | - |
dc.subject.keywordPlus | LUNG | - |
dc.subject.keywordPlus | PROGRAM | - |
dc.subject.keywordAuthor | ventricular assist device | - |
dc.subject.keywordAuthor | mechanical circulatory support | - |
dc.subject.keywordAuthor | pediatric patients | - |
dc.subject.keywordAuthor | hemodynamics | - |
dc.subject.keywordAuthor | biocompatibility | - |
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