Physiological and Pathological Significance of Dynamin-Related Protein 1 (Drp1)-Dependent Mitochondrial Fission in the Nervous SystemPhysiological and Pathological Significance of Dynamin-Related Protein 1 (Drp1)-Dependent Mitochondrial Fission in the Nervous System
- Other Titles
- Physiological and Pathological Significance of Dynamin-Related Protein 1 (Drp1)-Dependent Mitochondrial Fission in the Nervous System
- Authors
- 조봉기; 최소연; 조효민; 김현정; 선웅
- Issue Date
- 2013
- Publisher
- 한국뇌신경과학회
- Keywords
- Drp1; neurodegeneration; mitochondria; fission; neuron
- Citation
- Experimental Neurobiology, v.22, no.3, pp.149 - 157
- Indexed
- KCI
OTHER
- Journal Title
- Experimental Neurobiology
- Volume
- 22
- Number
- 3
- Start Page
- 149
- End Page
- 157
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/104904
- ISSN
- 1226-2560
- Abstract
- Mitochondria are essential for proper neuronal morphogenesis and functions, as they are the major source of energy for neural development. The dynamic morphology of mitochondria determines the key functions of mitochondria. Several regulatory proteins such as dynamin-related protein 1 (Drp1) are required to maintain mitochondrial morphology via a balance between continuous fusion and fission. Activity of Drp1, a key regulator in mitochondrial fission, is modulated by multiple post-translation modifications and receptor interactions. In addition, numerous researches have revealed that the regulation of Drp1 activity and mitochondrial dynamics is closely associated with several neurodegenerative diseases such as Alzheimer’s and Parkinson’s diseases. In this article, we concisely review the recent findings about the biological importance of Drp1-mediated mitochondrial fission in neurons under physiological and pathological conditions
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Collections - Graduate School > Department of Biomedical Sciences > 1. Journal Articles
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