The Role of Adiponectin in Secondary Inflammatory Reaction in Cerebral Ischemia
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 정용수 | - |
dc.contributor.author | 하성곤 | - |
dc.contributor.author | 김상대 | - |
dc.contributor.author | 김세훈 | - |
dc.contributor.author | 임동준 | - |
dc.contributor.author | 최종일 | - |
dc.date.accessioned | 2021-09-06T07:32:08Z | - |
dc.date.available | 2021-09-06T07:32:08Z | - |
dc.date.created | 2021-06-17 | - |
dc.date.issued | 2013 | - |
dc.identifier.issn | 2234-8565 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/105036 | - |
dc.description.abstract | Objective : In this study, we investigate the role of adiponectin in the interaction between leukocytes and endothelium in the secondary inflammatory reaction of cerebral ischemia Methods : Adiponectin knock-out mice group (APN-KO) (n = 8) and wild-type mice group (WT) (n = 8) were prepared. Each group was sub-divided into 2 groups by reperfusion time. One-hour middle cerebral artery occlusion and reperfusion were induced using the intraluminal filament technique. At 6 and 12 hours after the occlusion, the mice were placed on a stereotactic frame to perform craniotomy in the left parietal area. After craniotomy, a straight pial venule was selected as a target vessel. With the fluorescence intravital microscope, the number of rolling leukocytes and leukocytes that adhered to endothelium were counted and documented at 6 and 12 hours after the reperfusion. Results : At 6 and 12 hours after the reperfusion, more rolling leukocyte and leukocyte adhesion were observed in the APN-KO mice than in the WT mice. The difference in leukocyte numbers between the APN-KO and WT mice was found to be statistically significant (p = 0.029) by Mann-Whitney U-test. Conclusion : We found that adiponectin inhibits the interaction between the endothelium and leukocytes in cerebral ischemia-reperfusion. Therefore adiponectin might prevent the secondary insult caused by the inflammation reaction. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | 대한뇌혈관외과학회 | - |
dc.title | The Role of Adiponectin in Secondary Inflammatory Reaction in Cerebral Ischemia | - |
dc.title.alternative | The Role of Adiponectin in Secondary Inflammatory Reaction in Cerebral Ischemia | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | 하성곤 | - |
dc.contributor.affiliatedAuthor | 김상대 | - |
dc.contributor.affiliatedAuthor | 임동준 | - |
dc.identifier.doi | 10.7461/jcen.2013.15.3.171 | - |
dc.identifier.bibliographicCitation | Journal of Cerebrovascular and Endovascular Neurosurgery, v.15, no.3, pp.171 - 176 | - |
dc.relation.isPartOf | Journal of Cerebrovascular and Endovascular Neurosurgery | - |
dc.citation.title | Journal of Cerebrovascular and Endovascular Neurosurgery | - |
dc.citation.volume | 15 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 171 | - |
dc.citation.endPage | 176 | - |
dc.type.rims | ART | - |
dc.identifier.kciid | ART001807034 | - |
dc.description.journalClass | 2 | - |
dc.description.journalRegisteredClass | kci | - |
dc.description.journalRegisteredClass | other | - |
dc.subject.keywordAuthor | Adiponectin | - |
dc.subject.keywordAuthor | Cerebral ischemia | - |
dc.subject.keywordAuthor | Secondary inflammatory reaction | - |
dc.subject.keywordAuthor | MCAO-R | - |
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