Associations between the angiotensin-converting enzyme insertion/deletion polymorphism and susceptibility to vasculitis: a meta-analysis
DC Field | Value | Language |
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dc.contributor.author | Lee, Young Ho | - |
dc.contributor.author | Choi, Sung Jae | - |
dc.contributor.author | Ji, Jong Dae | - |
dc.contributor.author | Song, Gwan Gyu | - |
dc.date.accessioned | 2021-09-06T08:18:13Z | - |
dc.date.available | 2021-09-06T08:18:13Z | - |
dc.date.created | 2021-06-19 | - |
dc.date.issued | 2012-03 | - |
dc.identifier.issn | 1470-3203 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/105331 | - |
dc.description.abstract | Introduction: To explore whether the insertion (I) and deletion (D) polymorphism of angiotensin-converting enzyme (ACE) confers susceptibility to vasculitis. Materials and methods: A meta-analysis was conducted on the associations between the ACE I/D polymorphism and vasculitis. Results: Twelve studies, including four on Beh double dagger et's disease (BD), four on Henoch-Schenlein purpura (HSP), three on Kawasaki disease (KD), and one on Wegener's granulomatosis, were available for the meta-analysis. Meta-analysis showed that the DD + ID genotype was associated with susceptibility to vasculitis (odds ratio [OR] 1.468, 95% confidence interval [CI] 1.214-1.468, p = 7.4 x 10-5). The overall OR for the D allele was significantly increased in BD (OR 1.313, 95% CI 1.017-1.695). Meta-analysis of the DD+ID genotype, the DD genotype and the DD vs. II genotype showed marginal associations with BD, but meta-analysis of the D allele, and the DD+ID genotype showed significant associations with HSP (OR 1.446, 95% CI 1.021-2.049, p = 0.038; OR 1.881, 95% CI 1.385-2.595, p = 6.6 x 10-5). On the other hand, meta-analysis showed no association between KD and the ACE I/D polymorphism. Conclusions: This meta-analysis shows that the ACE I/D polymorphism is associated with vasculitis susceptibility, especially in BD and HSP. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | SAGE PUBLICATIONS LTD | - |
dc.subject | HENOCH-SCHONLEIN PURPURA | - |
dc.subject | SYSTEM GENE POLYMORPHISMS | - |
dc.subject | KAWASAKI-DISEASE | - |
dc.subject | BEHCETS-DISEASE | - |
dc.subject | DELETION POLYMORPHISM | - |
dc.subject | ACE GENE | - |
dc.subject | NEPHRITIS | - |
dc.subject | DIAGNOSIS | - |
dc.subject | CRITERIA | - |
dc.title | Associations between the angiotensin-converting enzyme insertion/deletion polymorphism and susceptibility to vasculitis: a meta-analysis | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Lee, Young Ho | - |
dc.contributor.affiliatedAuthor | Choi, Sung Jae | - |
dc.contributor.affiliatedAuthor | Song, Gwan Gyu | - |
dc.identifier.doi | 10.1177/1470320311434240 | - |
dc.identifier.scopusid | 2-s2.0-84859965690 | - |
dc.identifier.wosid | 000300993400025 | - |
dc.identifier.bibliographicCitation | JOURNAL OF THE RENIN-ANGIOTENSIN-ALDOSTERONE SYSTEM, v.13, no.1, pp.196 - 201 | - |
dc.relation.isPartOf | JOURNAL OF THE RENIN-ANGIOTENSIN-ALDOSTERONE SYSTEM | - |
dc.citation.title | JOURNAL OF THE RENIN-ANGIOTENSIN-ALDOSTERONE SYSTEM | - |
dc.citation.volume | 13 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 196 | - |
dc.citation.endPage | 201 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Cardiovascular System & Cardiology | - |
dc.relation.journalWebOfScienceCategory | Peripheral Vascular Disease | - |
dc.subject.keywordPlus | HENOCH-SCHONLEIN PURPURA | - |
dc.subject.keywordPlus | SYSTEM GENE POLYMORPHISMS | - |
dc.subject.keywordPlus | KAWASAKI-DISEASE | - |
dc.subject.keywordPlus | BEHCETS-DISEASE | - |
dc.subject.keywordPlus | DELETION POLYMORPHISM | - |
dc.subject.keywordPlus | ACE GENE | - |
dc.subject.keywordPlus | NEPHRITIS | - |
dc.subject.keywordPlus | DIAGNOSIS | - |
dc.subject.keywordPlus | CRITERIA | - |
dc.subject.keywordAuthor | Angiotensin-converting enzyme | - |
dc.subject.keywordAuthor | meta-analysis | - |
dc.subject.keywordAuthor | polymorphism | - |
dc.subject.keywordAuthor | vasculitis | - |
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