Lymphadenectomy increases the prognostic value of the revised 2009 FIGO staging system for endometrial cancer: A multi-center study
- Authors
- Kim, H. S.; Kim, H. Y.; Park, C. Y.; Lee, J. M.; Lee, J. K.; Cho, C. H.; Kim, S. M.; Kim, J. W.
- Issue Date
- 3월-2012
- Publisher
- ELSEVIER SCI LTD
- Keywords
- Lymphadenectomy; The revised 2009 FIGO staging system; Endometrial cancer
- Citation
- EJSO, v.38, no.3, pp.230 - 237
- Indexed
- SCIE
SCOPUS
- Journal Title
- EJSO
- Volume
- 38
- Number
- 3
- Start Page
- 230
- End Page
- 237
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/105345
- DOI
- 10.1016/j.ejso.2011.12.023
- ISSN
- 0748-7983
- Abstract
- Background: We investigated whether pelvic or para-aortic lymphadenectomy increases the prognostic value of the revised 2009 FIGO staging system in patients with endometrial cancer (EC). Methods: We reviewed 786 patients with EC from six tertiary medical centers between July 1996 and June 2008. All patients were classified according to the 1988 FIGO staging system: IA (n = 234); IB (n = 270); IC (n = 109); IIA (n = 35); IIB (n = 29); IIIA (n = 37); IIIB (n = 3); IIIC (n = 69), and the revised 2009 FIGO staging system was also applied to divide them: IA (=542); IB (=125); II (n = 29); IIIA (n = 18); IIIB (n = 3); IIIC I (n = 43); IIIC2 = 26). Prognostic values between the 1988 and the revised 2009 FIGO staging systems were compared by multivariate Cox's proportional hazard analysis. Results: The 1988 FIGO stage IC, IIB, IIIA + IIIB and IIIC, and the revised 2009 FIGO stage IB, II, IIIA + IIIB and IIIC2 diseases were prognostic factors for poor PFS, whereas the 1988 FIGO stage IIB and IIIC, and the revised 2009 FIGO stage 11, + IIIB and IIIC2 diseases were unfavorable prognostic factors for OS. Although these results were similar to those in 595 patients who underwent pelvic or para-aortic lymphadenectomy, the revised 2009 FIGO stage IIIC1 disease was an additional prognostic factor for poor PFS and OS (adjusted HRs, 4.19 and 11.25; 95% CIs, 1.39-12.60 and 2.23-36.74). Conclusions: The revised 2009 FIGO staging system had a higher prognostic value than the 1988 FIGO staging system, and pelvic or para-aortic lymphadenectomy increased the prognostic value of the revised 2009 FIGO staging system for EC. (C) 2011 Elsevier Ltd. All rights reserved.
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