Detailed Information

Cited 0 time in webofscience Cited 0 time in scopus
Metadata Downloads

Case-control association study of GRIA1, GRIA2 and GRIA4 polymorphisms in bipolar disorder

Authors
Chiesa, AlbertoCrisafulli, ConcettaPorcelli, StefanoBalzarro, BeatriceHan, ChangsuPatkar, Ashwin A.Lee, Soo-JungPark, Moon HoPae, Chi-UnSerretti, Alessandro
Issue Date
3월-2012
Publisher
TAYLOR & FRANCIS LTD
Keywords
GRIA1; GRIA2; GRIA4; bipolar disorder
Citation
INTERNATIONAL JOURNAL OF PSYCHIATRY IN CLINICAL PRACTICE, v.16, no.1, pp.18 - 26
Indexed
SCIE
SCOPUS
Journal Title
INTERNATIONAL JOURNAL OF PSYCHIATRY IN CLINICAL PRACTICE
Volume
16
Number
1
Start Page
18
End Page
26
URI
https://scholar.korea.ac.kr/handle/2021.sw.korea/105366
DOI
10.3109/13651501.2011.617459
ISSN
1365-1501
Abstract
Objective. The present study aimed to investigate whether some single nucleotide polymorphisms (SNPs) within GRIA1, GRIA2 and GRIA4 could be associated with bipolar disorder (BD) and they could predict clinical outcomes in in-patients with BD treated with mood stabilizers. Methods. One hundred and thirty-two (132) patients with BD and 170 healthy controls were genotyped for 17 SNPs within GRIA1, GRIA2 and GRIA4. Baseline and final clinical measures including Young Mania Rating Scale for patients with BD were recorded. Statistical significance was set at the 0.005 level in order to reduce the likelihood of false positive results. Results. We failed to show an evidence for a possible association of GRIA1, GRIA2 and GRIA4 with BD patients, in terms of influences on diagnosis and treatment outcomes, although this was the first study to explore the influence of such genes for bipolar disorder. Conclusion. Our results suggest that 17 SNPs within GRIA1, GRIA2 and GRIA4 may not be associated with the development and treatment outcomes in BD. However, taking into account that the several limitations of our study including the moderately small sample size of our study, our findings should be considered with caution and further research is needed to draw more definitive conclusions.
Files in This Item
There are no files associated with this item.
Appears in
Collections
College of Medicine > Department of Medical Science > 1. Journal Articles

qrcode

Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.

Related Researcher

Researcher Han, Chang su photo

Han, Chang su
의과대학 (의학과)
Read more

Altmetrics

Total Views & Downloads

BROWSE