소아청소년 틱장애 환자의 B림프구에서 D8/17의 발현D8/17 Expression on B Lymphocytes of Children and Adolescents with Tic Disorder
- Other Titles
- D8/17 Expression on B Lymphocytes of Children and Adolescents with Tic Disorder
- Authors
- 오영근; 박태원; 정용우; 정영철; 양종철; 정상근
- Issue Date
- 2013
- Publisher
- 대한소아청소년 정신의학회
- Keywords
- 틱장애·D8/17·ASO·PANDAS·FACS.; Tic Disorder; D8/17; ASO; PANDAS; FACS.
- Citation
- 소아 청소년 정신의학, v.24, no.3, pp.151 - 156
- Indexed
- KCI
- Journal Title
- 소아 청소년 정신의학
- Volume
- 24
- Number
- 3
- Start Page
- 151
- End Page
- 156
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/105833
- ISSN
- 1225-729X
- Abstract
- Objectives:It has been reported that higher percentage of B cells react with monoclonal D8/17 antibody in patients with rheumatic fever, childhood onset obsessive-compulsive disorder, Tourette’s disorder, or prepubertal anorexia nervosa. The purpose of this study is to replicate the previous studies in a Korean young population with tic disorder and to identify any relationship between D8/17 and clinical symptoms.
Methods:The binding of D8/17 to B cells was determined in patients with tic disorder (N=21) and healthy controls (N=9) by Fluorescence-Activated Cell Sorter analysis.
Results:In the sample examined by this study, the average percentage of B cells expressing D8/17 in tic disorder was 2.05%;healthy controls was 3.15%. No statistically significant differences were found in the mean percentages of D8/17 between the two groups.
Conclusion:The expression of D8/17 in B cells was very low in this study. No subjects with tic disorder or healthy controls was above 12% in D8/17 positive proportion. Further studies, including higher number of patients and control group members,should be performed.
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