Increased selenoprotein P levels in subjects with visceral obesity and nonalcoholic fatty liver disease
DC Field | Value | Language |
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dc.contributor.author | Choi, H.Y. | - |
dc.contributor.author | Hwang, S.Y. | - |
dc.contributor.author | Lee, C.H. | - |
dc.contributor.author | Hong, H.C. | - |
dc.contributor.author | Yang, S.J. | - |
dc.contributor.author | Yoo, H.J. | - |
dc.contributor.author | Seo, J.A. | - |
dc.contributor.author | Kim, S.G. | - |
dc.contributor.author | Kim, N.H. | - |
dc.contributor.author | Baik, S.H. | - |
dc.contributor.author | Choi, D.S. | - |
dc.contributor.author | Choi, K.M. | - |
dc.date.accessioned | 2021-09-06T09:40:37Z | - |
dc.date.available | 2021-09-06T09:40:37Z | - |
dc.date.created | 2021-06-17 | - |
dc.date.issued | 2013 | - |
dc.identifier.issn | 2233-6079 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/105859 | - |
dc.description.abstract | Background: Selenoprotein P (SeP) has recently been reported as a novel hepatokine that regulates insulin resistance and systemic energy metabolism in rodents and humans. We explored the associations among SeP, visceral obesity, and nonalcoholic fatty liver disease (NAFLD). Methods: We examined serum SeP concentrations in subjects with increased visceral fat area (VFA) or liver fat accumulation measured with computed tomography. Our study subjects included 120 nondiabetic individuals selected from participants of the Korean Sarcopenic Obesity Study. In addition, we evaluated the relationship between SeP and cardiometabolic risk factors, including homeostasis model of insulin resistance (HOMA-IR), high sensitivity C-reactive protein (hsCRP), adiponectin values, and brachial-ankle pulse wave velocity (baPWV). Results: Subjects with NAFLD showed increased levels of HOMA-IR, hsCRP, VFA, and several components of metabolic syndrome and decreased levels of adiponectin and high density lipoprotein cholesterol than those of controls. Serum SeP levels were positively correlated with VFA, hsCRP, and baPWV and negatively correlated with the liver attenuation index. Not only subjects with visceral obesity but also those with NAFLD exhibited significantly increased SeP levels (P<0.001). In multiple logistic regression analysis, the subjects in the highest SeP tertile showed a higher risk for NAFLD than those in the lowest SeP tertile, even after adjusting for potential confounding factors (odds ratio, 7.48; 95% confidence interval, 1.72 to 32.60; P=0.007). Conclusion: Circulating SeP levels were increased in subjects with NAFLD as well as in those with visceral obesity and may be a novel biomarker for NAFLD. © 2013 Korean Diabetes Association. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.subject | adiponectin | - |
dc.subject | alanine aminotransferase | - |
dc.subject | aspartate aminotransferase | - |
dc.subject | C reactive protein | - |
dc.subject | high density lipoprotein cholesterol | - |
dc.subject | low density lipoprotein cholesterol | - |
dc.subject | selenoprotein P | - |
dc.subject | triacylglycerol | - |
dc.subject | adult | - |
dc.subject | alanine aminotransferase blood level | - |
dc.subject | anthropometry | - |
dc.subject | article | - |
dc.subject | aspartate aminotransferase blood level | - |
dc.subject | cholesterol blood level | - |
dc.subject | cohort analysis | - |
dc.subject | computer assisted tomography | - |
dc.subject | controlled study | - |
dc.subject | disease association | - |
dc.subject | disease severity | - |
dc.subject | female | - |
dc.subject | homeostasis | - |
dc.subject | human | - |
dc.subject | hypertension | - |
dc.subject | insulin resistance | - |
dc.subject | lipid analysis | - |
dc.subject | major clinical study | - |
dc.subject | male | - |
dc.subject | nonalcoholic fatty liver | - |
dc.subject | obesity | - |
dc.subject | observational study | - |
dc.subject | prospective study | - |
dc.subject | protein blood level | - |
dc.subject | pulse wave | - |
dc.subject | triacylglycerol blood level | - |
dc.title | Increased selenoprotein P levels in subjects with visceral obesity and nonalcoholic fatty liver disease | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Baik, S.H. | - |
dc.identifier.doi | 10.4093/dmj.2013.37.1.63 | - |
dc.identifier.scopusid | 2-s2.0-84874952628 | - |
dc.identifier.bibliographicCitation | Diabetes and Metabolism Journal, v.37, no.1, pp.63 - 71 | - |
dc.relation.isPartOf | Diabetes and Metabolism Journal | - |
dc.citation.title | Diabetes and Metabolism Journal | - |
dc.citation.volume | 37 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 63 | - |
dc.citation.endPage | 71 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.identifier.kciid | ART001744604 | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
dc.subject.keywordPlus | adiponectin | - |
dc.subject.keywordPlus | alanine aminotransferase | - |
dc.subject.keywordPlus | aspartate aminotransferase | - |
dc.subject.keywordPlus | C reactive protein | - |
dc.subject.keywordPlus | high density lipoprotein cholesterol | - |
dc.subject.keywordPlus | low density lipoprotein cholesterol | - |
dc.subject.keywordPlus | selenoprotein P | - |
dc.subject.keywordPlus | triacylglycerol | - |
dc.subject.keywordPlus | adult | - |
dc.subject.keywordPlus | alanine aminotransferase blood level | - |
dc.subject.keywordPlus | anthropometry | - |
dc.subject.keywordPlus | article | - |
dc.subject.keywordPlus | aspartate aminotransferase blood level | - |
dc.subject.keywordPlus | cholesterol blood level | - |
dc.subject.keywordPlus | cohort analysis | - |
dc.subject.keywordPlus | computer assisted tomography | - |
dc.subject.keywordPlus | controlled study | - |
dc.subject.keywordPlus | disease association | - |
dc.subject.keywordPlus | disease severity | - |
dc.subject.keywordPlus | female | - |
dc.subject.keywordPlus | homeostasis | - |
dc.subject.keywordPlus | human | - |
dc.subject.keywordPlus | hypertension | - |
dc.subject.keywordPlus | insulin resistance | - |
dc.subject.keywordPlus | lipid analysis | - |
dc.subject.keywordPlus | major clinical study | - |
dc.subject.keywordPlus | male | - |
dc.subject.keywordPlus | nonalcoholic fatty liver | - |
dc.subject.keywordPlus | obesity | - |
dc.subject.keywordPlus | observational study | - |
dc.subject.keywordPlus | prospective study | - |
dc.subject.keywordPlus | protein blood level | - |
dc.subject.keywordPlus | pulse wave | - |
dc.subject.keywordPlus | triacylglycerol blood level | - |
dc.subject.keywordAuthor | Hepatokine | - |
dc.subject.keywordAuthor | Insulin resistance | - |
dc.subject.keywordAuthor | Non-alcoholic fatty liver disease | - |
dc.subject.keywordAuthor | Obesity | - |
dc.subject.keywordAuthor | Selenoprotein P | - |
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