Obesity associated hypertension: New insights into mechanism
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kang, Y.S. | - |
dc.date.accessioned | 2021-09-06T09:42:48Z | - |
dc.date.available | 2021-09-06T09:42:48Z | - |
dc.date.created | 2021-06-17 | - |
dc.date.issued | 2013 | - |
dc.identifier.issn | 1738-5997 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/105873 | - |
dc.description.abstract | With excess nutrition, the burden of obesity is a growing problem worldwide. The imbalance between energy intake and expenditure leads to variable disorders as all major risk factors for cardiovascular disease. There are many hypothetical mechanisms to explain obesity-associated hypertension. Activation of the RAAS is a key contributing factor in obesity. Particularly, the RAAS in adipose tissue plays a crucial role in adipose tissue dysfunction and obesity-induced inflammation. The phenotypic changes of adipocytes occur into hypertrophy and an inflammatory response in an autocrine and paracrine manner to impair adipocyte function, including insulin signaling pathway. Adipose tissue produce and secretes several molecules such as leptin, resistin, adiponectin, and visfatin, as well as cytokines such as TNF-α, IL-6, MCP-1, and IL-1. These adipokines are stimulated via the intracellular signaling pathways that regulate inflammation of adipose tissue. Inflammation and oxidative stress in adipose tissue are important to interact with the microvascular endothelium in the mechanisms of obesity-associated hypertension. Increased microvascular resistance raises blood pressure. Therefore, a regulatory link between microvascular and perivascular adipose tissue inflammation and adipokine synthesis are provided to explain the mechanism of obesity-associated hypertension. Copyright © 2013 The Korean Society of Electrolyte Metabolism. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | Korean Society of Electrolyte and Blood Pressure Research | - |
dc.subject | adipocytokine | - |
dc.subject | adiponectin | - |
dc.subject | cytokine | - |
dc.subject | insulin | - |
dc.subject | interleukin 1 | - |
dc.subject | interleukin 6 | - |
dc.subject | leptin | - |
dc.subject | monocyte chemotactic protein 1 | - |
dc.subject | neuropeptide | - |
dc.subject | nicotinamide phosphoribosyltransferase | - |
dc.subject | resistin | - |
dc.subject | tumor necrosis factor alpha | - |
dc.subject | adipocyte | - |
dc.subject | adipose tissue | - |
dc.subject | adrenergic system | - |
dc.subject | autocrine effect | - |
dc.subject | blood pressure | - |
dc.subject | caloric intake | - |
dc.subject | cardiovascular disease | - |
dc.subject | cytokine production | - |
dc.subject | disease association | - |
dc.subject | endothelial dysfunction | - |
dc.subject | energy expenditure | - |
dc.subject | human | - |
dc.subject | hyperinsulinemia | - |
dc.subject | hypertension | - |
dc.subject | hypertrophy | - |
dc.subject | inflammation | - |
dc.subject | intracellular signaling | - |
dc.subject | nonhuman | - |
dc.subject | obesity | - |
dc.subject | oxidative stress | - |
dc.subject | paracrine signaling | - |
dc.subject | phenotype | - |
dc.subject | renin angiotensin aldosterone system | - |
dc.subject | review | - |
dc.subject | risk factor | - |
dc.subject | signal transduction | - |
dc.subject | vascular endothelium | - |
dc.subject | vascular resistance | - |
dc.title | Obesity associated hypertension: New insights into mechanism | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Kang, Y.S. | - |
dc.identifier.doi | 10.5049/EBP.2013.11.2.46 | - |
dc.identifier.scopusid | 2-s2.0-84905658394 | - |
dc.identifier.bibliographicCitation | Electrolyte and Blood Pressure, v.11, no.2, pp.46 - 52 | - |
dc.relation.isPartOf | Electrolyte and Blood Pressure | - |
dc.citation.title | Electrolyte and Blood Pressure | - |
dc.citation.volume | 11 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 46 | - |
dc.citation.endPage | 52 | - |
dc.type.rims | ART | - |
dc.type.docType | Review | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
dc.description.journalRegisteredClass | other | - |
dc.subject.keywordPlus | adipocytokine | - |
dc.subject.keywordPlus | adiponectin | - |
dc.subject.keywordPlus | cytokine | - |
dc.subject.keywordPlus | insulin | - |
dc.subject.keywordPlus | interleukin 1 | - |
dc.subject.keywordPlus | interleukin 6 | - |
dc.subject.keywordPlus | leptin | - |
dc.subject.keywordPlus | monocyte chemotactic protein 1 | - |
dc.subject.keywordPlus | neuropeptide | - |
dc.subject.keywordPlus | nicotinamide phosphoribosyltransferase | - |
dc.subject.keywordPlus | resistin | - |
dc.subject.keywordPlus | tumor necrosis factor alpha | - |
dc.subject.keywordPlus | adipocyte | - |
dc.subject.keywordPlus | adipose tissue | - |
dc.subject.keywordPlus | adrenergic system | - |
dc.subject.keywordPlus | autocrine effect | - |
dc.subject.keywordPlus | blood pressure | - |
dc.subject.keywordPlus | caloric intake | - |
dc.subject.keywordPlus | cardiovascular disease | - |
dc.subject.keywordPlus | cytokine production | - |
dc.subject.keywordPlus | disease association | - |
dc.subject.keywordPlus | endothelial dysfunction | - |
dc.subject.keywordPlus | energy expenditure | - |
dc.subject.keywordPlus | human | - |
dc.subject.keywordPlus | hyperinsulinemia | - |
dc.subject.keywordPlus | hypertension | - |
dc.subject.keywordPlus | hypertrophy | - |
dc.subject.keywordPlus | inflammation | - |
dc.subject.keywordPlus | intracellular signaling | - |
dc.subject.keywordPlus | nonhuman | - |
dc.subject.keywordPlus | obesity | - |
dc.subject.keywordPlus | oxidative stress | - |
dc.subject.keywordPlus | paracrine signaling | - |
dc.subject.keywordPlus | phenotype | - |
dc.subject.keywordPlus | renin angiotensin aldosterone system | - |
dc.subject.keywordPlus | review | - |
dc.subject.keywordPlus | risk factor | - |
dc.subject.keywordPlus | signal transduction | - |
dc.subject.keywordPlus | vascular endothelium | - |
dc.subject.keywordPlus | vascular resistance | - |
dc.subject.keywordAuthor | Hypertension | - |
dc.subject.keywordAuthor | Insulin resistance | - |
dc.subject.keywordAuthor | Microvascular dysfunction | - |
dc.subject.keywordAuthor | Obesity | - |
dc.subject.keywordAuthor | Renin-angiotensin-aldosterone system (RAAS) | - |
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