Metabolomic Analysis Reveals Extended Metabolic Consequences of Marginal Vitamin B-6 Deficiency in Healthy Human Subjects
DC Field | Value | Language |
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dc.contributor.author | Gregory, III J.F. | - |
dc.contributor.author | Park, Y. | - |
dc.contributor.author | Lamers, Y. | - |
dc.contributor.author | Bandyopadhyay, N. | - |
dc.contributor.author | Chi, Y.-Y. | - |
dc.contributor.author | Lee, K. | - |
dc.contributor.author | Kim, S. | - |
dc.contributor.author | da, Silva V. | - |
dc.contributor.author | Hove, N. | - |
dc.contributor.author | Ranka, S. | - |
dc.contributor.author | Kahveci, T. | - |
dc.contributor.author | Muller, K.E. | - |
dc.contributor.author | Stevens, R.D. | - |
dc.contributor.author | Newgard, C.B. | - |
dc.contributor.author | Stacpoole, P.W. | - |
dc.contributor.author | Jones, D.P. | - |
dc.date.accessioned | 2021-09-06T09:44:56Z | - |
dc.date.available | 2021-09-06T09:44:56Z | - |
dc.date.created | 2021-06-17 | - |
dc.date.issued | 2013 | - |
dc.identifier.issn | 1932-6203 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/105886 | - |
dc.description.abstract | Marginal deficiency of vitamin B-6 is common among segments of the population worldwide. Because pyridoxal 5′-phosphate (PLP) serves as a coenzyme in the metabolism of amino acids, carbohydrates, organic acids, and neurotransmitters, as well as in aspects of one-carbon metabolism, vitamin B-6 deficiency could have many effects. Healthy men and women (age: 20-40 y; n = 23) were fed a 2-day controlled, nutritionally adequate diet followed by a 28-day low-vitamin B-6 diet (<0.5 mg/d) to induce marginal deficiency, as reflected by a decline of plasma PLP from 52.6±14.1 (mean ± SD) to 21.5±4.6 nmol/L (P<0.0001) and increased cystathionine from 131±65 to 199±56 nmol/L (P<0.001). Fasting plasma samples obtained before and after vitamin B6 restriction were analyzed by 1H-NMR with and without filtration and by targeted quantitative analysis by mass spectrometry (MS). Multilevel partial least squares-discriminant analysis and S-plots of NMR spectra showed that NMR is effective in classifying samples according to vitamin B-6 status and identified discriminating features. NMR spectral features of selected metabolites indicated that vitamin B-6 restriction significantly increased the ratios of glutamine/glutamate and 2-oxoglutarate/glutamate (P<0.001) and tended to increase concentrations of acetate, pyruvate, and trimethylamine-N-oxide (adjusted P<0.05). Tandem MS showed significantly greater plasma proline after vitamin B-6 restriction (adjusted P<0.05), but there were no effects on the profile of 14 other amino acids and 45 acylcarnitines. These findings demonstrate that marginal vitamin B-6 deficiency has widespread metabolic perturbations and illustrate the utility of metabolomics in evaluating complex effects of altered vitamin B-6 intake. © 2013 Gregory et al. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.subject | 2 oxoglutaric acid | - |
dc.subject | acetic acid | - |
dc.subject | acylcarnitine | - |
dc.subject | amino acid | - |
dc.subject | cystathionine | - |
dc.subject | glutamic acid | - |
dc.subject | glutamine | - |
dc.subject | proline | - |
dc.subject | pyridoxal 5 phosphate | - |
dc.subject | pyridoxine | - |
dc.subject | pyruvic acid | - |
dc.subject | trimethylamine oxide | - |
dc.subject | adult | - |
dc.subject | amino acid blood level | - |
dc.subject | article | - |
dc.subject | concentration response | - |
dc.subject | controlled study | - |
dc.subject | diet restriction | - |
dc.subject | female | - |
dc.subject | human | - |
dc.subject | human experiment | - |
dc.subject | male | - |
dc.subject | mass spectrometry | - |
dc.subject | metabolomics | - |
dc.subject | normal human | - |
dc.subject | proton nuclear magnetic resonance | - |
dc.subject | pyridoxine deficiency | - |
dc.subject | quantitative analysis | - |
dc.subject | vitamin blood level | - |
dc.subject | vitamin intake | - |
dc.subject | Acetates | - |
dc.subject | Adult | - |
dc.subject | Amino Acids | - |
dc.subject | Carnitine | - |
dc.subject | Cystathionine | - |
dc.subject | Female | - |
dc.subject | Glutamic Acid | - |
dc.subject | Glutamine | - |
dc.subject | Humans | - |
dc.subject | Ketoglutaric Acids | - |
dc.subject | Male | - |
dc.subject | Metabolomics | - |
dc.subject | Proline | - |
dc.subject | Pyridoxal Phosphate | - |
dc.subject | Vitamin B 6 | - |
dc.subject | Vitamin B 6 Deficiency | - |
dc.subject | Young Adult | - |
dc.title | Metabolomic Analysis Reveals Extended Metabolic Consequences of Marginal Vitamin B-6 Deficiency in Healthy Human Subjects | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Park, Y. | - |
dc.identifier.doi | 10.1371/journal.pone.0063544 | - |
dc.identifier.scopusid | 2-s2.0-84878913304 | - |
dc.identifier.bibliographicCitation | PLoS ONE, v.8, no.6 | - |
dc.relation.isPartOf | PLoS ONE | - |
dc.citation.title | PLoS ONE | - |
dc.citation.volume | 8 | - |
dc.citation.number | 6 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.subject.keywordPlus | 2 oxoglutaric acid | - |
dc.subject.keywordPlus | acetic acid | - |
dc.subject.keywordPlus | acylcarnitine | - |
dc.subject.keywordPlus | amino acid | - |
dc.subject.keywordPlus | cystathionine | - |
dc.subject.keywordPlus | glutamic acid | - |
dc.subject.keywordPlus | glutamine | - |
dc.subject.keywordPlus | proline | - |
dc.subject.keywordPlus | pyridoxal 5 phosphate | - |
dc.subject.keywordPlus | pyridoxine | - |
dc.subject.keywordPlus | pyruvic acid | - |
dc.subject.keywordPlus | trimethylamine oxide | - |
dc.subject.keywordPlus | adult | - |
dc.subject.keywordPlus | amino acid blood level | - |
dc.subject.keywordPlus | article | - |
dc.subject.keywordPlus | concentration response | - |
dc.subject.keywordPlus | controlled study | - |
dc.subject.keywordPlus | diet restriction | - |
dc.subject.keywordPlus | female | - |
dc.subject.keywordPlus | human | - |
dc.subject.keywordPlus | human experiment | - |
dc.subject.keywordPlus | male | - |
dc.subject.keywordPlus | mass spectrometry | - |
dc.subject.keywordPlus | metabolomics | - |
dc.subject.keywordPlus | normal human | - |
dc.subject.keywordPlus | proton nuclear magnetic resonance | - |
dc.subject.keywordPlus | pyridoxine deficiency | - |
dc.subject.keywordPlus | quantitative analysis | - |
dc.subject.keywordPlus | vitamin blood level | - |
dc.subject.keywordPlus | vitamin intake | - |
dc.subject.keywordPlus | Acetates | - |
dc.subject.keywordPlus | Adult | - |
dc.subject.keywordPlus | Amino Acids | - |
dc.subject.keywordPlus | Carnitine | - |
dc.subject.keywordPlus | Cystathionine | - |
dc.subject.keywordPlus | Female | - |
dc.subject.keywordPlus | Glutamic Acid | - |
dc.subject.keywordPlus | Glutamine | - |
dc.subject.keywordPlus | Humans | - |
dc.subject.keywordPlus | Ketoglutaric Acids | - |
dc.subject.keywordPlus | Male | - |
dc.subject.keywordPlus | Metabolomics | - |
dc.subject.keywordPlus | Proline | - |
dc.subject.keywordPlus | Pyridoxal Phosphate | - |
dc.subject.keywordPlus | Vitamin B 6 | - |
dc.subject.keywordPlus | Vitamin B 6 Deficiency | - |
dc.subject.keywordPlus | Young Adult | - |
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