Natural selection in a bangladeshi population from the cholera-endemic ganges river delta
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Karlsson, E.K. | - |
dc.contributor.author | Harris, J.B. | - |
dc.contributor.author | Tabrizi, S. | - |
dc.contributor.author | Rahman, A. | - |
dc.contributor.author | Shlyakhter, I. | - |
dc.contributor.author | Patterson, N. | - |
dc.contributor.author | O'Dushlaine, C. | - |
dc.contributor.author | Schaffner, S.F. | - |
dc.contributor.author | Gupta, S. | - |
dc.contributor.author | Chowdhury, F. | - |
dc.contributor.author | Sheikh, A. | - |
dc.contributor.author | Shin, O.S. | - |
dc.contributor.author | Ellis, C. | - |
dc.contributor.author | Becker, C.E. | - |
dc.contributor.author | Stuart, L.M. | - |
dc.contributor.author | Calderwood, S.B. | - |
dc.contributor.author | Ryan, E.T. | - |
dc.contributor.author | Qadri, F. | - |
dc.contributor.author | Sabeti, P.C. | - |
dc.contributor.author | LaRocque, R.C. | - |
dc.date.accessioned | 2021-09-06T09:48:06Z | - |
dc.date.available | 2021-09-06T09:48:06Z | - |
dc.date.created | 2021-06-17 | - |
dc.date.issued | 2013 | - |
dc.identifier.issn | 1946-6234 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/105906 | - |
dc.description.abstract | As an ancient disease with high fatality, cholera has likely exerted strong selective pressure on affected human populations. We performed a genome-wide study of natural selection in a population from the Ganges River Delta, the historic geographic epicenter of cholera. We identified 305 candidate selected regions using the composite of multiple signals (CMS) method. The regions were enriched for potassium channel genes involved in cyclic adenosine monophosphate-mediated chloride secretion and for components of the innate immune system involved in nuclear factor κB (NF-κB) signaling. We demonstrate that a number of these strongly selected genes are associated with cholera susceptibility in two separate cohorts. We further identify repeated examples of selection and association in an NF-κB/inflammasome-dependent pathway that is activated in vitro by Vibrio cholerae. Our findings shed light on the genetic basis of cholera resistance in a population from the Ganges River Delta and present a promising approach for identifying genetic factors influencing susceptibility to infectious diseases. Copyright 2013 by the American Association for the Advancement of Science; all rights reserved. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.subject | calcium activated potassium channel | - |
dc.subject | chloride | - |
dc.subject | cyclic AMP | - |
dc.subject | immunoglobulin enhancer binding protein | - |
dc.subject | inflammasome | - |
dc.subject | interleukin 1beta | - |
dc.subject | potassium channel | - |
dc.subject | voltage gated potassium channel | - |
dc.subject | adult | - |
dc.subject | animal cell | - |
dc.subject | article | - |
dc.subject | Bangladesh | - |
dc.subject | Bangladeshi | - |
dc.subject | child | - |
dc.subject | cholera | - |
dc.subject | controlled study | - |
dc.subject | endemic disease | - |
dc.subject | ethnic group | - |
dc.subject | female | - |
dc.subject | gene | - |
dc.subject | genetic analysis | - |
dc.subject | genetic distance | - |
dc.subject | genetic selection | - |
dc.subject | heredity | - |
dc.subject | human | - |
dc.subject | in vitro study | - |
dc.subject | infection resistance | - |
dc.subject | infection sensitivity | - |
dc.subject | innate immunity | - |
dc.subject | major clinical study | - |
dc.subject | male | - |
dc.subject | mouse | - |
dc.subject | natural selection | - |
dc.subject | nonhuman | - |
dc.subject | population genetics | - |
dc.subject | potassium channel gene | - |
dc.subject | priority journal | - |
dc.subject | river | - |
dc.subject | signal transduction | - |
dc.subject | single nucleotide polymorphism | - |
dc.subject | Vibrio cholerae | - |
dc.subject | Cholera | - |
dc.subject | Genetic Predisposition to Disease | - |
dc.subject | Humans | - |
dc.subject | Inflammasomes | - |
dc.subject | NF-kappa B | - |
dc.subject | Rivers | - |
dc.subject | Selection, Genetic | - |
dc.subject | Vibrio cholerae | - |
dc.title | Natural selection in a bangladeshi population from the cholera-endemic ganges river delta | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Shin, O.S. | - |
dc.identifier.doi | 10.1126/scitranslmed.3006338 | - |
dc.identifier.scopusid | 2-s2.0-84880540798 | - |
dc.identifier.bibliographicCitation | Science Translational Medicine, v.5, no.192 | - |
dc.relation.isPartOf | Science Translational Medicine | - |
dc.citation.title | Science Translational Medicine | - |
dc.citation.volume | 5 | - |
dc.citation.number | 192 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.subject.keywordPlus | calcium activated potassium channel | - |
dc.subject.keywordPlus | chloride | - |
dc.subject.keywordPlus | cyclic AMP | - |
dc.subject.keywordPlus | immunoglobulin enhancer binding protein | - |
dc.subject.keywordPlus | inflammasome | - |
dc.subject.keywordPlus | interleukin 1beta | - |
dc.subject.keywordPlus | potassium channel | - |
dc.subject.keywordPlus | voltage gated potassium channel | - |
dc.subject.keywordPlus | adult | - |
dc.subject.keywordPlus | animal cell | - |
dc.subject.keywordPlus | article | - |
dc.subject.keywordPlus | Bangladesh | - |
dc.subject.keywordPlus | Bangladeshi | - |
dc.subject.keywordPlus | child | - |
dc.subject.keywordPlus | cholera | - |
dc.subject.keywordPlus | controlled study | - |
dc.subject.keywordPlus | endemic disease | - |
dc.subject.keywordPlus | ethnic group | - |
dc.subject.keywordPlus | female | - |
dc.subject.keywordPlus | gene | - |
dc.subject.keywordPlus | genetic analysis | - |
dc.subject.keywordPlus | genetic distance | - |
dc.subject.keywordPlus | genetic selection | - |
dc.subject.keywordPlus | heredity | - |
dc.subject.keywordPlus | human | - |
dc.subject.keywordPlus | in vitro study | - |
dc.subject.keywordPlus | infection resistance | - |
dc.subject.keywordPlus | infection sensitivity | - |
dc.subject.keywordPlus | innate immunity | - |
dc.subject.keywordPlus | major clinical study | - |
dc.subject.keywordPlus | male | - |
dc.subject.keywordPlus | mouse | - |
dc.subject.keywordPlus | natural selection | - |
dc.subject.keywordPlus | nonhuman | - |
dc.subject.keywordPlus | population genetics | - |
dc.subject.keywordPlus | potassium channel gene | - |
dc.subject.keywordPlus | priority journal | - |
dc.subject.keywordPlus | river | - |
dc.subject.keywordPlus | signal transduction | - |
dc.subject.keywordPlus | single nucleotide polymorphism | - |
dc.subject.keywordPlus | Vibrio cholerae | - |
dc.subject.keywordPlus | Cholera | - |
dc.subject.keywordPlus | Genetic Predisposition to Disease | - |
dc.subject.keywordPlus | Humans | - |
dc.subject.keywordPlus | Inflammasomes | - |
dc.subject.keywordPlus | NF-kappa B | - |
dc.subject.keywordPlus | Rivers | - |
dc.subject.keywordPlus | Selection, Genetic | - |
dc.subject.keywordPlus | Vibrio cholerae | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
(02841) 서울특별시 성북구 안암로 14502-3290-1114
COPYRIGHT © 2021 Korea University. All Rights Reserved.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.